This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5n6c
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate== | |
| - | + | <StructureSection load='5n6c' size='340' side='right' caption='[[5n6c]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5n6c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N6C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_dehydrogenase Phosphoglycerate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.95 1.1.1.95] </span></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n6c OCA], [http://pdbe.org/5n6c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n6c RCSB], [http://www.ebi.ac.uk/pdbsum/5n6c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n6c ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| + | [[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Phosphoglycerate dehydrogenase]] | ||
[[Category: Basle, A]] | [[Category: Basle, A]] | ||
| + | [[Category: Cano, C]] | ||
| + | [[Category: Curtin, N J]] | ||
| + | [[Category: Noble, M E.M]] | ||
[[Category: Tucker, J]] | [[Category: Tucker, J]] | ||
| - | [[Category: | + | [[Category: Unterlass, J E]] |
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Enzymology]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Serine metabolism]] | ||
Revision as of 07:37, 22 November 2017
Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate
| |||||||||||
