2bsd
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bsd OCA], [http://www.ebi.ac.uk/pdbsum/2bsd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bsd RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2BSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 2BSD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactococcus_lactis_phage_p2 Lactococcus lactis phage p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BSD OCA]. |
==Reference== | ==Reference== | ||
Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses., Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C, Nat Struct Mol Biol. 2006 Jan;13(1):85-9. Epub 2005 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16327804 16327804] | Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses., Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C, Nat Struct Mol Biol. 2006 Jan;13(1):85-9. Epub 2005 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16327804 16327804] | ||
| - | [[Category: Lactococcus lactis phage | + | [[Category: Lactococcus lactis phage p2]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cambillau, C.]] | [[Category: Cambillau, C.]] | ||
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[[Category: receptor binding protein]] | [[Category: receptor binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:06 2008'' |
Revision as of 23:11, 30 March 2008
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| , resolution 2.30Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF LACTOCOCCAL BACTERIOPHAGE P2 RECEPTOR BINDING PROTEIN
Overview
Lactococcus lactis is a Gram-positive bacterium used extensively by the dairy industry for the manufacture of fermented milk products. The double-stranded DNA bacteriophage p2 infects specific L. lactis strains using a receptor-binding protein (RBP) located at the tip of its noncontractile tail. We have solved the crystal structure of phage p2 RBP, a homotrimeric protein composed of three domains: the shoulders, a beta-sandwich attached to the phage; the neck, an interlaced beta-prism; and the receptor-recognition head, a seven-stranded beta-barrel. We used the complex of RBP with a neutralizing llama VHH domain to identify the receptor-binding site. Structural similarity between the recognition-head domain of phage p2 and those of adenoviruses and reoviruses, which invade mammalian cells, suggests that these viruses, despite evolutionary distant targets, lack of sequence similarity and the different chemical nature of their genomes (DNA versus RNA), might have a common ancestral gene.
About this Structure
2BSD is a Single protein structure of sequence from Lactococcus lactis phage p2. Full crystallographic information is available from OCA.
Reference
Lactococcal bacteriophage p2 receptor-binding protein structure suggests a common ancestor gene with bacterial and mammalian viruses., Spinelli S, Desmyter A, Verrips CT, de Haard HJ, Moineau S, Cambillau C, Nat Struct Mol Biol. 2006 Jan;13(1):85-9. Epub 2005 Dec 4. PMID:16327804
Page seeded by OCA on Mon Mar 31 02:11:06 2008
