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4mt2

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Revision as of 07:20, 29 November 2017

COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2

Structural highlights

4mt2 is a 1 chain structure with sequence from Black rat. This structure supersedes the now removed PDB entries 2mt2 and 1mt2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MT2_RAT] Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. & Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.

Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.,Braun W, Vasak M, Robbins AH, Stout CD, Wagner G, Kagi JH, Wuthrich K Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8. PMID:1438200^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Braun W, Vasak M, Robbins AH, Stout CD, Wagner G, Kagi JH, Wuthrich K. Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8. PMID:1438200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4mt2"

Categories: Black rat | Robbins, A H | Stout, C D | Metallothionein

@@ Line 1: / Line 1: @@
 ==COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2==
 <StructureSection load='4mt2' size='340' side='right' caption='[[4mt2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt2 OCA], [http://pdbe.org/4mt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt2 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt2 OCA], [http://pdbe.org/4mt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mt2 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt2 ProSAT]</span></td></tr>
 </table>
 == Function ==

4mt2

From Proteopedia

Revision as of 07:20, 29 November 2017

COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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