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Terminase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Terminase''' (Ter) is a key component of the DNA packaging machine found in bacteriophages and herpesviruses. The Ter complex is comprised of a small Ter which is a recognition subunit and a large Ter which is an endonuclease/translocase subunit <ref>PMID:22297528</ref>. | + | '''Terminase''' (Ter) is a key component of the DNA packaging machine found in bacteriophages and herpesviruses. The Ter complex is comprised of a small Ter subunit which is a recognition subunit and a large Ter subunit which is an endonuclease/translocase subunit <ref>PMID:22297528</ref>. The nuclease activity of the large Ter subunit is stimulated by ATP. |
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== Structural highlights == | == Structural highlights == | ||
| - | + | The large subunit of Ter is composed of an N-terminal ATPase domain, a linker region and a C-terminal nuclease domain. ATP binds to the protein in a groove between the ATPase domain and the linker region<ref>PMID:23630261</ref>. | |
</StructureSection> | </StructureSection> | ||
== 3D Structures of terminase == | == 3D Structures of terminase == | ||
Revision as of 08:29, 3 December 2017
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3D Structures of terminase
Updated on 03-December-2017
References
- ↑ Feiss M, Rao VB. The bacteriophage DNA packaging machine. Adv Exp Med Biol. 2012;726:489-509. doi: 10.1007/978-1-4614-0980-9_22. PMID:22297528 doi:http://dx.doi.org/10.1007/978-1-4614-0980-9_22
- ↑ Zhao H, Christensen TE, Kamau YN, Tang L. Structures of the phage Sf6 large terminase provide new insights into DNA translocation and cleavage. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8075-8080. Epub 2013 Apr 29. PMID:23630261 doi:10.1073/pnas.1301133110
