Mandelate racemase/muconate lactonizing enzyme

Function

Mandelate racemase/muconate lactonizing enzyme (MRMLP) is an enolase family dipeptide epimerase. Other members of th family are D-mannonate dehydratase, L-talarate dehydratase, L-rhamnonate dehydratase, D-glucarate dehydratase, Galacturonate dehydratase, Tartarate dehydratase, L-fuconate dehydratase and N-succinyl Arg/Lys racemate. The D-mannonate dehydratase catalyzes the syn-hydration of D-mannonate.

Disease

Relevance

Structural highlights

The D-mannonate dehydratase has two domains: the N-terminal α+β domain and a (β/α)₇ β-barrel domain. The active site of the enzyme is found on the interface of the dimer^[1].