Sodium-hydrogen exchange regulatory factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. | + | '''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane.<ref>PMID:26010555</ref>. |
| - | == | + | == Relevance == |
| - | + | NHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure<ref>PMID:12223070</ref>. NHERF-1 has a vital role in kidney cell survival<ref>PMID:25680790</ref>. NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke. | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:53, 26 December 2017
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3D Structures of sodium-hydrogen exchange regulatory factor
Updated on 26-December-2017
References
- ↑ Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan;158(1):57-62. doi: 10.1016/S0002-9440(10)63944-2. PMID:11141479 doi:http://dx.doi.org/10.1016/S0002-9440(10)63944-2
- ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932
- ↑ Morris K. Targeting the myocardial sodium-hydrogen exchange for treatment of heart failure. Expert Opin Ther Targets. 2002 Jun;6(3):291-8. doi: 10.1517/14728222.6.3.291 . PMID:12223070 doi:http://dx.doi.org/10.1517/14728222.6.3.291
- ↑ Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub , 2015 Feb 14. PMID:25680790 doi:http://dx.doi.org/10.1007/s00018-015-1848-8
