6bw3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide== | |
| - | + | <StructureSection load='6bw3' size='340' side='right' caption='[[6bw3]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw3 OCA], [http://pdbe.org/6bw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MDS1_HUMAN MDS1_HUMAN]] A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.<ref>PMID:8643684</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Halabelian, L]] | ||
[[Category: Hutchinson, A]] | [[Category: Hutchinson, A]] | ||
| - | [[Category: | + | [[Category: Ivanochko, D]] |
| + | [[Category: Structural genomic]] | ||
[[Category: Seitova, A]] | [[Category: Seitova, A]] | ||
| - | [[Category: | + | [[Category: Chromatin regulator]] |
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Epigenetic]] |
| - | [[Category: | + | [[Category: Gene regulation]] |
| - | [[Category: | + | [[Category: Histone-binding protein]] |
| + | [[Category: Nucleus]] | ||
| + | [[Category: Nurd]] | ||
| + | [[Category: Repressor]] | ||
| + | [[Category: Sgc]] | ||
| + | [[Category: Wd repeat]] | ||
Revision as of 08:39, 27 December 2017
Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide
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