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Cathepsin

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Line 99: Line 99:
**[[5t6u]] – mMCTSK<br />
**[[5t6u]] – mMCTSK<br />
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br />
**[[3o1g]], [[3n3g]], [[2r6n]], [[1bgo]], [[3kwz]], [[3kx1]], [[3o0u]] – hMCTSK+ pyrimidine inhibitor<br />
-
**[[3mpe]], [[3mpf]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
+
**[[5qby]], [[5qbv]] – hMCTSK (mutant) + pyrimidine inhibitor<br />
**[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
**[[3h7d]] - hMCTSK (mutant) + chondroitin-4-sulfate<br />
**[[3c9e]], [[4n8w]] - hMCTSK + chondroitin-4-sulfate<br />
**[[3c9e]], [[4n8w]] - hMCTSK + chondroitin-4-sulfate<br />
Line 171: Line 171:
**[[3ovx]] - hMCTSS+ aldehyde inhibitor<br />
**[[3ovx]] - hMCTSS+ aldehyde inhibitor<br />
**[[3ovz]] - hMCTSS+ ketoamide inhibitor<br />
**[[3ovz]] - hMCTSS+ ketoamide inhibitor<br />
-
**[[3kwn]] – hMCTSS (mutant)+ thioether acetamide<br />
+
**[[5qc4]] – hMCTSS (mutant)+ thioether acetamide<br />
**[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br />
**[[3iej]] - hMCTSS (mutant)+pyrazole inhibitor<br />
**[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />
**[[2h7j]], [[2hxz]]- hMCTSS+triazole inhibitor<br />

Revision as of 16:01, 28 December 2017

human cathepsin B complex with inhibitor 3ai8

Drag the structure with the mouse to rotate

3D Structures of Cathepsin

Updated on 28-December-2017


References

  1. ↑ Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells. J Med Invest. 2005 Feb;52(1-2):1-9. PMID:15751268
  2. ↑ Mirkovic B, Renko M, Turk S, Sosic I, Jevnikar Z, Obermajer N, Turk D, Gobec S, Kos J. Novel Mechanism of Cathepsin B Inhibition by Antibiotic Nitroxoline and Related Compounds. ChemMedChem. 2011 May 20. doi: 10.1002/cmdc.201100098. PMID:21598397 doi:10.1002/cmdc.201100098

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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