This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6elq
From Proteopedia
(Difference between revisions)
m (Protected "6elq" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Carbon Monoxide Dehydrogenase IV from Carboxydothermus hydrogenoformans== | |
| + | <StructureSection load='6elq' size='340' side='right' caption='[[6elq]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6elq]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ELQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ELQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BF8:FE(4)-NI(1)-S(5)+CLUSTER+with+Oxygen'>BF8</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Anaerobic_carbon-monoxide_dehydrogenase Anaerobic carbon-monoxide dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.7.4 1.2.7.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6elq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6elq OCA], [http://pdbe.org/6elq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6elq RCSB], [http://www.ebi.ac.uk/pdbsum/6elq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6elq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CO dehydrogenases (CODHs) catalyse the reversible conversion between CO and CO2 . Genomic analysis indicated that the metabolic functions of CODHs vary. The genome of Carboxydothermus hydrogenoformans encodes five CODHs (CODH-I-V), of which CODH-IV is found in a gene cluster near a peroxide-reducing enzyme. Our kinetic and crystallographic experiments reveal that CODH-IV differs from other CODHs in several characteristic properties: it has a very high affinity for CO, oxidizes CO at diffusion-limited rate over a wide range of temperatures, and is more tolerant to oxygen than CODH-II. Thus, our observations support the idea that CODH-IV is a CO scavenger in defence against oxidative stress and highlight that CODHs are more diverse in terms of reactivity than expected. | ||
| - | + | CODH-IV: A High-Efficiency CO-Scavenging CO Dehydrogenase with Resistance to O2.,Domnik L, Merrouch M, Goetzl S, Jeoung JH, Leger C, Dementin S, Fourmond V, Dobbek H Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15466-15469. doi:, 10.1002/anie.201709261. Epub 2017 Nov 2. PMID:29024326<ref>PMID:29024326</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6elq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Anaerobic carbon-monoxide dehydrogenase]] | ||
[[Category: Dobbek, H]] | [[Category: Dobbek, H]] | ||
[[Category: Domnik, L]] | [[Category: Domnik, L]] | ||
| - | [[Category: Jeoung, J.H]] | ||
[[Category: Goetzl, S]] | [[Category: Goetzl, S]] | ||
| + | [[Category: Jeoung, J H]] | ||
| + | [[Category: Anaerobiosis]] | ||
| + | [[Category: Carbon dioxide]] | ||
| + | [[Category: Carbon monoxide]] | ||
| + | [[Category: Crystallization]] | ||
| + | [[Category: Iron]] | ||
| + | [[Category: Ligand]] | ||
| + | [[Category: Nickel]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Recombinant protein]] | ||
Revision as of 05:52, 3 January 2018
Carbon Monoxide Dehydrogenase IV from Carboxydothermus hydrogenoformans
| |||||||||||
