6b7z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain== | |
| - | + | <StructureSection load='6b7z' size='340' side='right' caption='[[6b7z]], [[Resolution|resolution]] 6.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b7z]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B7Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6b7y|6b7y]], [[6b70|6b70]], [[6b3q|6b3q]]</td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b7z OCA], [http://pdbe.org/6b7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b7z RCSB], [http://www.ebi.ac.uk/pdbsum/6b7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b7z ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Insulysin]] | ||
| + | [[Category: Bailey, L J]] | ||
[[Category: Carragher, B]] | [[Category: Carragher, B]] | ||
| + | [[Category: Kossiakoff, A A]] | ||
| + | [[Category: Liang, W G]] | ||
| + | [[Category: Potter, S C]] | ||
| + | [[Category: Tan, Y Z]] | ||
| + | [[Category: Tang, W J]] | ||
| + | [[Category: Wei, H]] | ||
[[Category: Zhang, Z]] | [[Category: Zhang, Z]] | ||
| - | [[Category: | + | [[Category: Amyloid beta]] |
| - | [[Category: | + | [[Category: Biosynthetic protein]] |
| - | [[Category: | + | [[Category: Hydrolase-immune system complex]] |
| - | [[Category: | + | [[Category: Ide]] |
| - | [[Category: | + | [[Category: Insulin degrading enzyme]] |
Revision as of 08:31, 10 January 2018
Cryo-EM structure of human insulin degrading enzyme in complex with FAB H11 heavy chain and FAB H11 light chain
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