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Sodium-hydrogen exchange regulatory factor

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== Function ==
== Function ==
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'''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
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'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
== Relevance ==
== Relevance ==
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*Sodium-hydrogen exchange regulatory factor 1
*Sodium-hydrogen exchange regulatory factor 1
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**[[1g9o]], [[1gq5]] – hNHERF-1 PDZ 1 domain – human <br />
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**[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br />
**[[2m0t]] – hNHERF-1 PDZ 1 domain - NMR <br />
**[[2m0t]] – hNHERF-1 PDZ 1 domain - NMR <br />
**[[1i92]], [[4jl7]], [[4lmm]], [[4mpa]], [[4n6x]] - hNHERF-1 PDZ 1 domain/CFTR C-terminal peptide <br />
**[[1i92]], [[4jl7]], [[4lmm]], [[4mpa]], [[4n6x]] - hNHERF-1 PDZ 1 domain/CFTR C-terminal peptide <br />
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**[[4q3h]] – hNHERF-1 PDZ 2 domain/CXCR2 peptide <br />
**[[4q3h]] – hNHERF-1 PDZ 2 domain/CXCR2 peptide <br />
**[[2jxo]], [[2kjd]] – hNHERF-1 PDZ 2 domain - NMR <br />
**[[2jxo]], [[2kjd]] – hNHERF-1 PDZ 2 domain - NMR <br />
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**[[2m0w]] – hNHERF-1 PDZ 2 domain + CFTR C-terminal peptide - NMR <br />
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**[[2m0w]], [[2m0v]] – hNHERF-1 PDZ 2 domain + CFTR C-terminal peptide - NMR <br />
**[[2krg]] – hNHERF-1 residues 150-358 - NMR <br />
**[[2krg]] – hNHERF-1 residues 150-358 - NMR <br />

Revision as of 11:11, 14 January 2018

Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

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3D Structures of sodium-hydrogen exchange regulatory factor

Updated on 14-January-2018

References

  1. ↑ Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan;158(1):57-62. doi: 10.1016/S0002-9440(10)63944-2. PMID:11141479 doi:http://dx.doi.org/10.1016/S0002-9440(10)63944-2
  2. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932
  3. ↑ Morris K. Targeting the myocardial sodium-hydrogen exchange for treatment of heart failure. Expert Opin Ther Targets. 2002 Jun;6(3):291-8. doi: 10.1517/14728222.6.3.291 . PMID:12223070 doi:http://dx.doi.org/10.1517/14728222.6.3.291
  4. ↑ Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub , 2015 Feb 14. PMID:25680790 doi:http://dx.doi.org/10.1007/s00018-015-1848-8
  5. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932

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