Spindlin

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<StructureSection load='4mzg' size='400' side='right' caption='Human spindlin-1 (skyblue) complex with histone H3 peptide (whet) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code [[4mzg]])' scene='77/778344/Cv/1'>
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<StructureSection load='4mzg' size='400' side='right' caption='Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code [[4mzg]])' scene='77/778344/Cv/1'>
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== Structural highlights ==
== Structural highlights ==
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The crystal complex of SPIN1 and histone H3 peptide shows the encapsulation of the histone trimethyllysine and its Arg in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>.
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The crystal complex of SPIN1 and histone H3 peptide shows the <scene name='77/778344/Cv/2'>encapsulation of the histone trimethyllysine</scene> and its Arg in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>.
</StructureSection>
</StructureSection>
== 3D Structures of spindlin ==
== 3D Structures of spindlin ==

Revision as of 11:13, 23 January 2018

Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code 4mzg)

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3D Structures of spindlin

Updated on 23-January-2018

References

  1. ↑ Wang W, Chen Z, Mao Z, Zhang H, Ding X, Chen S, Zhang X, Xu R, Zhu B. Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes. EMBO Rep. 2011 Oct 28;12(11):1160-6. doi: 10.1038/embor.2011.184. PMID:21960006 doi:http://dx.doi.org/10.1038/embor.2011.184
  2. ↑ Franz H, Greschik H, Willmann D, Ozretic L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schule R. The histone code reader SPIN1 controls RET signaling in liposarcoma. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. PMID:25749382 doi:http://dx.doi.org/10.18632/oncotarget.3000
  3. ↑ Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W, Li H. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. doi: 10.1101/gad.233239.113. Epub 2014 Mar, 3. PMID:24589551 doi:http://dx.doi.org/10.1101/gad.233239.113

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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