User:Karsten Theis/FadA5 thiolase
From Proteopedia
< User:Karsten Theis(Difference between revisions)
(→Structure of Fad A5) |
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==Fighting tuberculosis== | ==Fighting tuberculosis== | ||
| + | Space for an introduction to tuberculosis resistance | ||
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==Structure of Fad A5== | ==Structure of Fad A5== | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='600' side='right' caption='Fad A5 thiolase' scene='77/778945/Subdomain/2'> |
FadA5 thiolase has three <scene name='77/778945/Subdomain/2'>subdomains</scene> (I: 1-125,246-266; II: 126-245; III: 267-391) | FadA5 thiolase has three <scene name='77/778945/Subdomain/2'>subdomains</scene> (I: 1-125,246-266; II: 126-245; III: 267-391) | ||
| - | and forms a <scene name='77/778945/Dimer/ | + | and forms a <scene name='77/778945/Dimer/2'>dimer</scene>. |
The following structures have been determined: | The following structures have been determined: | ||
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* [[4ubu]] The inactive C93S variant in complex with CoA | * [[4ubu]] The inactive C93S variant in complex with CoA | ||
* [[4ubt]] The inactive C93S variant in complex with a cleaved product (CoA and a cholesterol | * [[4ubt]] The inactive C93S variant in complex with a cleaved product (CoA and a cholesterol | ||
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| + | <scene name='77/778945/Coaac/5'>acetylated CoA binds to FadA5</scene> | ||
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| + | Same with <scene name='77/778945/Coaac/4'>labels</scene> | ||
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| + | connect 2.5 4.0 (visible and WAT)(visible) HBOND | ||
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| + | blue: 177, 221, 224, 242, 243, 151 | ||
| + | |||
| + | green: 377, 315, 317, 343, 173, | ||
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| + | orange: 17, 248, 246, 93 | ||
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| + | all: 377, 315, 317, 343, 173, 177, 221, 224, 242, 243, 151, 17, 248, 246, 93 | ||
</StructureSection> | </StructureSection> | ||
Current revision
Fighting tuberculosis
Space for an introduction to tuberculosis resistance
Structure of Fad A5
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