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4eaz

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Current revision (05:46, 31 January 2018) (edit) (undo)
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{{STRUCTURE_4eaz| PDB=4eaz | SCENE= }}
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#REDIRECT [[5z2q]] This PDB entry is obsolete and replaced by 5z2q
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===Vgll1-TEAD4 structure===
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{{ABSTRACT_PUBMED_22632831}}
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==Function==
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[[http://www.uniprot.org/uniprot/VGLL1_MOUSE VGLL1_MOUSE]] May act as a specific coactivator for the mammalian TEFs (By similarity). [[http://www.uniprot.org/uniprot/TEAD4_MOUSE TEAD4_MOUSE]] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle.
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==About this Structure==
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[[4eaz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EAZ OCA].
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==Reference==
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<ref group="xtra">PMID:022632831</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Pobbati, A V.]]
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[[Category: Song, H.]]
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[[Category: Beta sandwich]]
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[[Category: Immunoglobulin]]
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[[Category: Transcription]]
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[[Category: Vgll1]]
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Current revision

  1. REDIRECT 5z2q This PDB entry is obsolete and replaced by 5z2q

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