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5ug7

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'''Unreleased structure'''
 
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The entry 5ug7 is ON HOLD until Paper Publication
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==Calcium bound Perforin C2 Domain - T431D==
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<StructureSection load='5ug7' size='340' side='right' caption='[[5ug7]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ug7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UG7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UG7 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ug6|5ug6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ug7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ug7 OCA], [http://pdbe.org/5ug7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ug7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ug7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ug7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Conroy, P J]]
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[[Category: Law, R H.P]]
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[[Category: Voskoboinik, I]]
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[[Category: Whisstock, J C]]
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[[Category: Apoptosis]]
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[[Category: C2]]
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[[Category: Calcium]]
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[[Category: Perforin]]
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[[Category: Proteostasis]]

Revision as of 06:12, 7 February 2018

Calcium bound Perforin C2 Domain - T431D

5ug7, resolution 1.80Å

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