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Sandbox Reserved 1411
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==Structure== | ==Structure== | ||
| - | EPO is made up of a 166 amino acid chain. There are 4 <scene name='77/777731/Alpha_helices/1'>alpha helices</scene> shown in red which are arranged in a bundle. In the tertiary structure, there are two disulfide bonds, shown in yellow, which hold together this bundle. There are two active sites | + | EPO is made up of a 166 amino acid chain. There are 4 <scene name='77/777731/Alpha_helices/1'>alpha helices</scene> shown in red which are arranged in a bundle. In the tertiary structure, there are two disulfide bonds, shown in yellow, which hold together this bundle. There are two active sites for this protein. <scene name='77/777731/Active_site_one/1'>Site one</scene> is responsible for binding to the receptor on cell surfaces. <scene name='77/777731/Active_site_2/1'>Site two</scene> causes dimerization with other EPO subunits. |
== Function == | == Function == | ||
EPO receptors in the bone marrow triggers a signal transduction pathway that causes red blood cells to move into the blood stream. | EPO receptors in the bone marrow triggers a signal transduction pathway that causes red blood cells to move into the blood stream. | ||
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==References== | ==References== | ||
https://www.rcsb.org/structure/1buy | https://www.rcsb.org/structure/1buy | ||
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https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/anemia | https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/anemia | ||
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https://www.ncbi.nlm.nih.gov/pubmed/9002951 | https://www.ncbi.nlm.nih.gov/pubmed/9002951 | ||
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https://www.ncbi.nlm.nih.gov/pubmed/9783743 | https://www.ncbi.nlm.nih.gov/pubmed/9783743 | ||
Current revision
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Erythropoietin
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