Thyroid hormone receptor

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== Structural highlights ==
== Structural highlights ==
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The thyroid hormone binds in the ligand niche making several interactions with TR<ref>PMID:15466465</ref>.
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The <scene name='78/781020/Cv/2'>thyroid hormone binds in the ligand niche making several interactions with TR</scene><ref>PMID:15466465</ref>.
</StructureSection>
</StructureSection>

Revision as of 13:29, 19 February 2018

Structure of human thyroid hormone receptor ligand-binding domain complex with thyroid hormone and cacodylate (PDB entry 1xzx)

Drag the structure with the mouse to rotate

3D Structures of thyroid hormone receptor

Updated on 19-February-2018

References

  1. Forrest D, Erway LC, Ng L, Altschuler R, Curran T. Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet. 1996 Jul;13(3):354-7. doi: 10.1038/ng0796-354. PMID:8673137 doi:http://dx.doi.org/10.1038/ng0796-354
  2. Cheng SY. Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance. Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82. doi:, 10.1016/j.tem.2005.03.008. PMID:15860414 doi:http://dx.doi.org/10.1016/j.tem.2005.03.008
  3. Kim WG, Cheng SY. Thyroid hormone receptors and cancer. Biochim Biophys Acta. 2013 Jul;1830(7):3928-36. doi:, 10.1016/j.bbagen.2012.04.002. Epub 2012 Apr 6. PMID:22507269 doi:http://dx.doi.org/10.1016/j.bbagen.2012.04.002
  4. Kunitake JM, Hartman N, Henson LC, Lieberman J, Williams DE, Wong M, Hershman JM. 3,5,3'-triiodothyroacetic acid therapy for thyroid hormone resistance. J Clin Endocrinol Metab. 1989 Aug;69(2):461-6. doi: 10.1210/jcem-69-2-461. PMID:2753985 doi:http://dx.doi.org/10.1210/jcem-69-2-461
  5. Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD. Thyroxine-thyroid hormone receptor interactions. J Biol Chem. 2004 Dec 31;279(53):55801-8. Epub 2004 Oct 4. PMID:15466465 doi:10.1074/jbc.M410124200

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Michal Harel, Alexander Berchansky

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