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5n8m

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'''Unreleased structure'''
 
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The entry 5n8m is ON HOLD
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==Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)==
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<StructureSection load='5n8m' size='340' side='right' caption='[[5n8m]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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Authors: Masliah, G., Maris, C., Allain, H.-T.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5n8m]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8M FirstGlance]. <br>
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Description: Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8m OCA], [http://pdbe.org/5n8m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8m RCSB], [http://www.ebi.ac.uk/pdbsum/5n8m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8m ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRBP2_HUMAN TRBP2_HUMAN]] Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.<ref>PMID:12475984</ref> <ref>PMID:16271387</ref> <ref>PMID:16142218</ref> <ref>PMID:16357216</ref> <ref>PMID:15973356</ref> <ref>PMID:16424907</ref> <ref>PMID:17452327</ref> <ref>PMID:18178619</ref> <ref>PMID:19219043</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Allain, H T.F]]
[[Category: Maris, C]]
[[Category: Maris, C]]
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[[Category: Allain, H.-T.F]]
 
[[Category: Masliah, G]]
[[Category: Masliah, G]]
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[[Category: Protein-rna complex]]
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[[Category: Rna binding protein]]
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[[Category: Rnai]]
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[[Category: Sirna]]
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[[Category: Trbp]]

Revision as of 07:10, 22 February 2018

Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A)

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