Sandbox Reserved 1382

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==Globular Actin==
==Globular Actin==
<StructureSection load='3hbt' size='340' side='right' caption='Caption for this structure' scene=''>
<StructureSection load='3hbt' size='340' side='right' caption='Caption for this structure' scene=''>
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Globular actin is a monomer that is composed of a larger cleft (active site) and a smaller cleft (allosteric site). Ser14, Ser33, His73, Glu72, Tyr69 are hydrophilic residues of active site. The tertiary structure consists of four major subdomains. Subdomain 1 and 3 form the smaller cleft and subdomain 2 and 4 form the larger cleft. It is filamentous when polymerized (F-actin).<ref>doi:10.2210/rcsb_pdb/mom_2001_7</ref>
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Globular actin is a monomer that is composed of a larger cleft (active site) and a smaller cleft (allosteric site). <scene name='77/777702/Hydphil_res_of_active_site/1'>Ser14, Ser33, His73, Glu72, Tyr69</scene> are hydrophilic residues of active site. The tertiary structure consists of four major subdomains. Subdomain 1 and 3 form the smaller cleft and subdomain 2 and 4 form the larger cleft. It is filamentous when polymerized (F-actin).<ref>doi:10.2210/rcsb_pdb/mom_2001_7</ref>
== Function ==
== Function ==
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Actin provides unique advantages that make this solution more dependable, flexible, and scalable than alternatives. Actin is self-propelled, operates independently, and has small dimensions which makes it able to explore the dense grid network in a parallel manner. ATP is used to power the computation, which eliminates the need of an electric potential to be delivered from a single point of access, which makes powering larger SSP computations realistic. The molecular motor attached to the F-actin is also much more power efficient than traditional computers, effectively eliminating heat dissipation limitations.<ref>doi:10.1073/pnas.1510825113</ref> The actin design can be mass produced as a computing agent for all NP-complete problems since the nature of the problem is inherently encoded into the grid network. Furthermore, actin can also replenish itself through enzymatic splitting and elongation.
Actin provides unique advantages that make this solution more dependable, flexible, and scalable than alternatives. Actin is self-propelled, operates independently, and has small dimensions which makes it able to explore the dense grid network in a parallel manner. ATP is used to power the computation, which eliminates the need of an electric potential to be delivered from a single point of access, which makes powering larger SSP computations realistic. The molecular motor attached to the F-actin is also much more power efficient than traditional computers, effectively eliminating heat dissipation limitations.<ref>doi:10.1073/pnas.1510825113</ref> The actin design can be mass produced as a computing agent for all NP-complete problems since the nature of the problem is inherently encoded into the grid network. Furthermore, actin can also replenish itself through enzymatic splitting and elongation.
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[[Image:Figure 4..png|frame|center|15px]]
 
The preliminary test run on a 3 number SSP provides error rate too high to be within a reasonable margin of error for SSPs with more than 10 numbers (Fig. 4). The error is a direct result of the failure of pass junctions to force 100% of F-actin to traverse in a straight path.<ref>doi:10.1073/pnas.1510825113</ref> Still, the success rate for SSPs with less than 10 variables is acceptable enough to be a viable method of parallel computation.
The preliminary test run on a 3 number SSP provides error rate too high to be within a reasonable margin of error for SSPs with more than 10 numbers (Fig. 4). The error is a direct result of the failure of pass junctions to force 100% of F-actin to traverse in a straight path.<ref>doi:10.1073/pnas.1510825113</ref> Still, the success rate for SSPs with less than 10 variables is acceptable enough to be a viable method of parallel computation.

Revision as of 21:46, 22 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Globular Actin

Caption for this structure

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References

  1. ↑ doi: https://dx.doi.org/10.2210/rcsb_pdb/mom_2001_7
  2. ↑ Dominguez R, Holmes KC. Actin structure and function. Annu Rev Biophys. 2011;40:169-86. doi: 10.1146/annurev-biophys-042910-155359. PMID:21314430 doi:http://dx.doi.org/10.1146/annurev-biophys-042910-155359
  3. ↑ Nicolau DV Jr, Lard M, Korten T, van Delft FC, Persson M, Bengtsson E, Mansson A, Diez S, Linke H, Nicolau DV. Parallel computation with molecular-motor-propelled agents in nanofabricated networks. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2591-6. doi:, 10.1073/pnas.1510825113. Epub 2016 Feb 22. PMID:26903637 doi:http://dx.doi.org/10.1073/pnas.1510825113
  4. ↑ Nicolau DV Jr, Lard M, Korten T, van Delft FC, Persson M, Bengtsson E, Mansson A, Diez S, Linke H, Nicolau DV. Parallel computation with molecular-motor-propelled agents in nanofabricated networks. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2591-6. doi:, 10.1073/pnas.1510825113. Epub 2016 Feb 22. PMID:26903637 doi:http://dx.doi.org/10.1073/pnas.1510825113
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