Sandbox GGC2

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==Glucokinase==
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==Your Heading Here (maybe something like 'Structure')==
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<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene='75/752269/Intro/1'>
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<StructureSection load='3VEV' size='340' side='right' caption='Caption for this structure' scene=''>
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Glucokinase is also known as human hexokinase IV <ref>DOI 10.1074/jbc.M111.274126</ref>. It is an enzyme that involves in the regulation of glucose homeostasis. Liver and pancreatic cells use glucokinase converts glucose molecule to glucose 6 phosphate.
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This is a default text for your page '''Sandbox GGC2'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Structure and Function==
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== Function ==
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Glucokinase is a protein contains 465 amino acid residues which make up two domains, including a <scene name='75/752269/Small_domain__green/1'>small domain and a large domain</scene>, colored in green and blue, respectively.
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When glucose molecule binds to the <scene name='75/752269/Gkactivesite_glucose/4'>active site</scene> of glucoskinase, it forms hydrogen bonds with <scene name='75/752269/Gkactivesite_glucose/2'>Asn 204, Asp 205, Asn 231, Glu 256 and Glu 290</scene>. At the allosteric site, either glucokinase activators (GKA) or glucokinase inhibitor (GKI) will bind to regulate the activity of glucokinase by changing the conformation. JSmol structure shows an example of <scene name='75/752269/Gkallosteric/1'>GK-GKA complex</scene>, where the GKA bind to the allosteric site. The allosteric site is composed of 3 hydrophobic pockets which are made up of different amino acid residues colored in pink, green, and purple <ref>DOI 10.2174/1875397300802010076</ref>. Among these ammino acid residues, different residues will form hydrogen bond corresponding to different ligands that bind to the site.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Revision as of 18:54, 23 February 2018

Your Heading Here (maybe something like 'Structure')

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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