2f2b
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= aqpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus]) | |GENE= aqpM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2evu|2evu]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2b OCA], [http://www.ebi.ac.uk/pdbsum/2f2b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f2b RCSB]</span> | ||
}} | }} | ||
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[[Category: Remis, J.]] | [[Category: Remis, J.]] | ||
[[Category: Stroud, R M.]] | [[Category: Stroud, R M.]] | ||
| - | [[Category: GOL]] | ||
[[Category: channel]] | [[Category: channel]] | ||
[[Category: integral membrane protein]] | [[Category: integral membrane protein]] | ||
[[Category: protein]] | [[Category: protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:56:59 2008'' |
Revision as of 23:57, 30 March 2008
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| , resolution 1.68Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | aqpM (Methanothermobacter thermautotrophicus) | ||||||
| Related: | 2evu
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of integral membrane protein Aquaporin AqpM at 1.68A resolution
Overview
To explore the structural basis of the unique selectivity spectrum and conductance of the transmembrane channel protein AqpM from the archaeon Methanothermobacter marburgensis, we determined the structure of AqpM to 1.68-A resolution by x-ray crystallography. The structure establishes AqpM as being in a unique subdivision between the two major subdivisions of aquaporins, the water-selective aquaporins, and the water-plus-glycerol-conducting aquaglyceroporins. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies.
About this Structure
2F2B is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.
Reference
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A., Lee JK, Kozono D, Remis J, Kitagawa Y, Agre P, Stroud RM, Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18932-7. Epub 2005 Dec 16. PMID:16361443
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