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2f6m
From Proteopedia
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|PDB= 2f6m |SIZE=350|CAPTION= <scene name='initialview01'>2f6m</scene>, resolution 2.10Å | |PDB= 2f6m |SIZE=350|CAPTION= <scene name='initialview01'>2f6m</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=DDQ:DECYLAMINE-N,N-DIMETHYL-N-OXIDE'>DDQ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= STP22, VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS28, VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= STP22, VPS23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), VPS28, VPT28 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1u5t|1U5T]], [[2f66|2F66]], [[1w7p|1W7P]], [[1uzx|1UZX]], [[1xb4|1XB4]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6m OCA], [http://www.ebi.ac.uk/pdbsum/2f6m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f6m RCSB]</span> | ||
}} | }} | ||
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[[Category: Kostelansky, M S.]] | [[Category: Kostelansky, M S.]] | ||
[[Category: Lee, S.]] | [[Category: Lee, S.]] | ||
| - | [[Category: DDQ]] | ||
| - | [[Category: MG]] | ||
[[Category: endosomal sorting complex required for transport]] | [[Category: endosomal sorting complex required for transport]] | ||
[[Category: endosome]] | [[Category: endosome]] | ||
| Line 39: | Line 40: | ||
[[Category: vps28]] | [[Category: vps28]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:58:39 2008'' |
Revision as of 23:58, 30 March 2008
| |||||||
| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | STP22, VPS23 (Saccharomyces cerevisiae), VPS28, VPT28 (Saccharomyces cerevisiae) | ||||||
| Related: | 1U5T, 2F66, 1W7P, 1UZX, 1XB4
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of a Vps23-C:Vps28-N subcomplex
Overview
The endosomal sorting complex required for transport (ESCRT) complexes are central to receptor downregulation, lysosome biogenesis, and budding of HIV. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37. The crystal structures of a Vps23:Vps28 core subcomplex and the Vps23:Vps28:Vps37 core were solved at 2.1 and 2.8 A resolution. Each subunit contains a structurally similar pair of helices that form the core. The N-terminal domain of Vps28 has a hydrophobic binding site on its surface that is conformationally dynamic. The C-terminal domain of Vps28 binds the ESCRT-II complex. The structure shows how ESCRT-I is assembled by a compact core from which the Vps23 UEV domain, the Vps28 C domain, and other domains project to bind their partners.
About this Structure
2F6M is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structural and functional organization of the ESCRT-I trafficking complex., Kostelansky MS, Sun J, Lee S, Kim J, Ghirlando R, Hierro A, Emr SD, Hurley JH, Cell. 2006 Apr 7;125(1):113-26. PMID:16615894
Page seeded by OCA on Mon Mar 31 02:58:39 2008
