Sandbox Reserved 1382
From Proteopedia
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| - | {{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==Globular Actin (G-actin)== | ==Globular Actin (G-actin)== | ||
<StructureSection load='3hbt' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3hbt' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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| + | == Structure == | ||
Globular actin (G-actin) is a monomer that is composed of a larger cleft (active site) and a smaller cleft (allosteric site). <scene name='77/777702/Hydphil_res_of_active_site/1'>Ser14, Ser33, His73, Glu72, Tyr69</scene> are hydrophilic residues of active site. The tertiary structure consists of four major subdomains. <scene name='77/777702/Subdom_1_and_3/1'>Subdomains 1 and 3</scene> form the smaller cleft and <scene name='77/777702/Subdom_2_and_4/1'>subdomains 2 and 4</scene> form the larger cleft. The active site is located within subdomain 2. It is filamentous when polymerized (F-actin).<ref>doi:10.2210/rcsb_pdb/mom_2001_7</ref> | Globular actin (G-actin) is a monomer that is composed of a larger cleft (active site) and a smaller cleft (allosteric site). <scene name='77/777702/Hydphil_res_of_active_site/1'>Ser14, Ser33, His73, Glu72, Tyr69</scene> are hydrophilic residues of active site. The tertiary structure consists of four major subdomains. <scene name='77/777702/Subdom_1_and_3/1'>Subdomains 1 and 3</scene> form the smaller cleft and <scene name='77/777702/Subdom_2_and_4/1'>subdomains 2 and 4</scene> form the larger cleft. The active site is located within subdomain 2. It is filamentous when polymerized (F-actin).<ref>doi:10.2210/rcsb_pdb/mom_2001_7</ref> | ||
== Function == | == Function == | ||
| - | G-actin can be polymerized to form filamentous F-actin. It is involved in cell motility in prokaryotic and eukaryotic cells. It builds a ladder on which the myosin filament climbs, which in turn causes muscle contractions and other cell movements. It also maintains structure and makes up some of the cytoskeleton of the cell. It orients cellular processes based on space and time.<ref>doi:10.1146/annurev-biophys-042910-155359</ref> | + | G-actin can be polymerized to form filamentous F-actin. It is involved in cell motility in prokaryotic and eukaryotic cells. It builds a ladder on which the <scene name='77/777702/Actin-tropomyosin-myosin/1'>myosin filament</scene> climbs, which in turn causes muscle contractions and other cell movements. It also maintains structure and makes up some of the cytoskeleton of the cell. It orients cellular processes based on space and time.<ref>doi:10.1146/annurev-biophys-042910-155359</ref> |
== Relevance and applications == | == Relevance and applications == | ||
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== References == | == References == | ||
| - | https://www.rcsb.org/structure/3hbt | ||
| - | http://proteopedia.org/wiki/index.php/Non-polymerizable_monomeric_actin | ||
| - | https://docs.google.com/presentation/d/1DNBY9ykH7yl9MO4QSp4G86HEyhbMvznpBvlZs_rGOCY/edit#slide=id.g29fda9e754_0_0 | ||
| - | https://docs.google.com/document/d/1Yw_4G4XPA5Wu2AUTeDVvhgyO6cSQvjp9S_RxfgUIwXY/edit?ts=5a984750 | ||
<references/> | <references/> | ||
Current revision
Globular Actin (G-actin)
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