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Adhesin
From Proteopedia
(Difference between revisions)
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Bacterial pathogens use adhesins as a major factor in adhesion-based virulence. Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>. | Bacterial pathogens use adhesins as a major factor in adhesion-based virulence. Adhesins serve as vaccine targets since they are essential to infection<ref>PMID:10341176</ref>. | ||
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| + | == Structural highlights == | ||
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*<scene name='70/705684/Cv/2'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]]).<ref>PMID:23277582</ref> | *<scene name='70/705684/Cv/2'>Adhesin PsaA complex with galactose, acetate and tert-butyl formate</scene> (PDB ID [[4f8p]]).<ref>PMID:23277582</ref> | ||
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**[[3zk8]], [[3zk9]], [[3zka]] – SpPsaA (mutant)<br /> | **[[3zk8]], [[3zk9]], [[3zka]] – SpPsaA (mutant)<br /> | ||
**[[5cyl]] – PsaA subunit CUPB6 - ''Pseudomonas aeruginosa''<br /> | **[[5cyl]] – PsaA subunit CUPB6 - ''Pseudomonas aeruginosa''<br /> | ||
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| - | *Epitheial adhesin | ||
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| - | **[[4d3w]], [[4asl]], [[4af9]] – CgAdh epithelial 1 A domain – ''Candida glabrata''<br /> | ||
| - | **[[4afc]], [[4afb]], [[4afa]] – CgAdh epithelial 1 A domain (mutant)<br /> | ||
| - | **[[4cp2]], [[4cp1]], [[4cp0]] – CgAdh epithelial 9 A domain <br /> | ||
| - | **[[4coz]], [[4coy]], [[4cow]], [[4cov]], [[4cou]] – CgAdh epithelial 6 A domain <br /> | ||
* Fimbrial adhesion complex | * Fimbrial adhesion complex | ||
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**[[4f8o]] – YpPsaA + lactose + inhibitor <BR /> | **[[4f8o]] – YpPsaA + lactose + inhibitor <BR /> | ||
**[[4f8p]] – YpPsaA + galactose <BR /> | **[[4f8p]] – YpPsaA + galactose <BR /> | ||
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| + | *Epitheial adhesin | ||
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| + | **[[4d3w]], [[4asl]], [[4af9]] – CgAdh epithelial 1 A domain – ''Candida glabrata''<br /> | ||
| + | **[[4afc]], [[4afb]], [[4afa]] – CgAdh epithelial 1 A domain (mutant)<br /> | ||
| + | **[[4cp2]], [[4cp1]], [[4cp0]] – CgAdh epithelial 9 A domain <br /> | ||
| + | **[[4coz]], [[4coy]], [[4cow]], [[4cov]], [[4cou]] – CgAdh epithelial 6 A domain <br /> | ||
*Collagen adhesin (CAdh) | *Collagen adhesin (CAdh) | ||
Revision as of 08:00, 7 March 2018
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3D Structures of adhesin
Updated on 07-March-2018
References
- ↑ Klemm P, Schembri MA. Bacterial adhesins: function and structure. Int J Med Microbiol. 2000 Mar;290(1):27-35. PMID:11043979 doi:http://dx.doi.org/10.1016/S1438-4221(00)80102-2
- ↑ Wizemann TM, Adamou JE, Langermann S. Adhesins as targets for vaccine development. Emerg Infect Dis. 1999 May-Jun;5(3):395-403. doi: 10.3201/eid0503.990310. PMID:10341176 doi:http://dx.doi.org/10.3201/eid0503.990310
- ↑ Bao R, Nair MK, Tang WK, Esser L, Sadhukhan A, Holland RL, Xia D, Schifferli DM. Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1065-70. doi:, 10.1073/pnas.1212431110. Epub 2012 Dec 31. PMID:23277582 doi:10.1073/pnas.1212431110
