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2fbe
From Proteopedia
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|PDB= 2fbe |SIZE=350|CAPTION= <scene name='initialview01'>2fbe</scene>, resolution 2.52Å | |PDB= 2fbe |SIZE=350|CAPTION= <scene name='initialview01'>2fbe</scene>, resolution 2.52Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= gene 19q13.4.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= gene 19q13.4.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbe OCA], [http://www.ebi.ac.uk/pdbsum/2fbe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fbe RCSB]</span> | ||
}} | }} | ||
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[[Category: jellyroll beta-sandwich fold]] | [[Category: jellyroll beta-sandwich fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:00:27 2008'' |
Revision as of 00:00, 31 March 2008
| |||||||
| , resolution 2.52Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | gene 19q13.4.1 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the PRYSPRY-domain
Overview
We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.
About this Structure
2FBE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases., Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG, FEBS Lett. 2006 Jan 9;580(1):99-106. Epub 2005 Dec 9. PMID:16364311
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