Aminopeptidase

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Line 47: Line 47:
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
-
**[[4fke]] – pAla-AP + Zn – pig<br />
+
**[[4fke]], [[5lds]], [[5lg6]] – pAla-AP + Zn – pig<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
**[[4fkh]] – pAla-AP + Zn + alanine<br />
**[[4naq]], [[4nz8]] – pAla-AP + Zn + polyalanine<br />
**[[4naq]], [[4nz8]] – pAla-AP + Zn + polyalanine<br />
Line 67: Line 67:
**[[4q4i]] – EcAPN+ Zn + peptide<br />
**[[4q4i]] – EcAPN+ Zn + peptide<br />
**[[4q4e]] – EcAPN+ Zn + actinonin<br />
**[[4q4e]] – EcAPN+ Zn + actinonin<br />
-
**[[4ou3]] – pAPN+ Zn + peptide<br />
+
**[[5mfr]], [[5mfs]], [[5mft]] – EcAPN+ Zn + aminobenzosuberone<br />
 +
**[[4ou3]] – pAPN+ Zn + polypeptide<br />
 +
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
 +
**[[5lhd]] – hAPN+ Zn <br />
 +
**[[6atk]] – hAPN+ Zn + spike glycoprotein<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
Line 75: Line 79:
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[4fgm]] – AP N + Zn – ''Idiomarina loihiensis''<br />
**[[4fgm]] – AP N + Zn – ''Idiomarina loihiensis''<br />
 +
 +
*Aminopeptidase P
 +
 +
**[[5wze]] – PaAPP + Ala + Pro – ''Pseudomonas aeruginosa''<br />
*Proline aminopeptidase
*Proline aminopeptidase
Line 107: Line 115:
**[[3azp]] - SmPro-AP (mutant)<br />
**[[3azp]] - SmPro-AP (mutant)<br />
**[[3azq]] - SmPro-AP (mutant) + PGG<br />
**[[3azq]] - SmPro-AP (mutant) + PGG<br />
 +
**[[4s2r]] – CePro-AP 1 + Zn - ''Caenorhabditis elegans'' <br />
 +
**[[4s2t]] – CePro-AP 1 + Zn + apstatin <br />
*Leucine aminopeptidase
*Leucine aminopeptidase
Line 115: Line 125:
**[[5jh9]] – yLeu-AP 1 (mutant) + Zn<br />
**[[5jh9]] – yLeu-AP 1 (mutant) + Zn<br />
**[[3jru]] – Leu-AP – ''Xanthomonas oryzae''<br />
**[[3jru]] – Leu-AP – ''Xanthomonas oryzae''<br />
-
**[[2hc9]], [[2hb6]] – Leu-AP – ''Caenorhabditis elegans''<br />
+
**[[2hc9]], [[2hb6]] – CeLeu-AP <br />
**[[2ewb]] – bLeu-AP+zofenoprilat – bovine<br />
**[[2ewb]] – bLeu-AP+zofenoprilat – bovine<br />
**[[1lam]], [[1lap]] – bLue-AP<br />
**[[1lam]], [[1lap]] – bLue-AP<br />
Line 148: Line 158:
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
 +
**[[5ntg]], [[5ntf]] – Leu-AP – ''Trypanosoma cruzi''<br />
 +
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
 +
**[[5gne]] – Leu-AP + Zn – ''Legionella pneumophila''<br />
*Leucine-cysteine aminopeptidase
*Leucine-cysteine aminopeptidase
-
**[[4p8q]], [[5c97]] – hLeu-Cys-AP + Zn<br />
+
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
Line 167: Line 180:
**[[4fo7]], [[4juq]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
**[[4fo7]], [[4juq]] - PaMet-AP+Mn – ''Pseudomonas aeruginosa''<br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
**[[4fo8]] - PaMet-AP+Mn + Met <br />
-
**[[4hxx]], [[4iu6]] - hMet-AP 1 + Co + pyrimidine derivative<br />
 
-
**[[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 +Mn+inhibitor<br />
 
-
**[[2b3h]], [[2b3k]] - hMet-AP 1 +Co<br />
 
-
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]] – hMet-AP 1 +Co+inhibitor<br />
 
-
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
 
-
**[[2ea2]], [[2ea4]], [[2ga2]] - hMet-AP 2 +Mn+inhibitor<br />
 
-
**[[1boa]] - hMet-AP 2 +Co+ angiogenesis inhibitor<br />
 
-
**[[1kq0]], [[1kq9]] – hMet-AP 2 +methionine<br />
 
-
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]] - hMet-AP 2 +Co+inhibitor<br />
 
-
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
 
-
**[[1r58]], [[1r5g]], [[1r5h]] - hMet-AP 2 +Mn+inhibitor<br />
 
**[[3iu7]] – MtMet-AP+Mn +A02 – ''Mycobacterium tuberculosis''<br />
**[[3iu7]] – MtMet-AP+Mn +A02 – ''Mycobacterium tuberculosis''<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
Line 183: Line 185:
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pka]] - MtMet-AP+Mn<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
**[[3pkb]], [[3pkc]], [[3pkd]], [[3pke]] - MtMet-AP+bengamide inhibitor<br />
-
**[[3tav]] – Met-AP + Mg – ''Mycobacterium abscessus''< br />
 
**[[1y1n]] - MtMet-AP+K<br />
**[[1y1n]] - MtMet-AP+K<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
**[[4idy]], [[4iec]] - MtMet-AP+K + hydroxyethyl disulfide<br />
Line 199: Line 200:
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u76]], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
**[[2mat]], [[4mat]], [[4u76]], [[4u75]], [[4u73]], [[4u71]], [[4u70]], [[4u6z]], [[4u6w]], [[4u6j]], [[4u6e]], [[4u6c]], [[4u76]], [[4u1b]] - EcMet-AP 1 (mutant)+Co<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
-
**[[4fli]], [[4flj]], [[4flk]], [[4fll]] - hMet-AP 1 +Mn+inhibitor<br />
 
**[[1qxw]], [[1qxy]], [[1qxz]] – Met-AP+Co+inhibitor - ''Staphylococcus aureus''<br />
**[[1qxw]], [[1qxy]], [[1qxz]] – Met-AP+Co+inhibitor - ''Staphylococcus aureus''<br />
**[[1o0x]] – TmMet-AP<br />
**[[1o0x]] – TmMet-AP<br />
**[[3s6b]] – PfMet-AP + Fe <br />
**[[3s6b]] – PfMet-AP + Fe <br />
-
**[[4fuk]] – TbMet-AP + Zn – ''Trypanosoma brucei''<br />
+
**[[4fuk]] – TbMet-AP + Zn <br />
**[[4km3]] – SpAP<br />
**[[4km3]] – SpAP<br />
 +
**[[3tav]] – Met-AP + Mg – ''Mycobacterium abscessus''< br />
 +
 +
*Human methionine aminopeptidase
 +
 +
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
 +
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]] – hMet-AP 1 + Co + inhibitor<br />
 +
**[[4fli]], [[4flj]], [[4flk]], [[4fll]], [[2nq6]], [[2nq7]], [[1yw7]], [[1yw8]], [[1yw9]] - hMet-AP 1 + Mn +inhibitor<br />
 +
**[[2g6p]] - hMet-AP 1 truncated+Mn+inhibitor<br />
 +
**[[1boa]] - hMet-AP 2 +Co+ angiogenesis inhibitor<br />
 +
**[[1kq0]], 1kq9]] – hMet-AP 2 +methionine<br />
 +
**[[1qzy]], [[1b59]], [[1b6a]], [[1bn5]], [[2oaz]], [[5d6f]], [[5d6e]], [[5cls]] - hMet-AP 2 +Co+inhibitor<br />
 +
**[[2adu]] - hMet-AP 2 (mutant) +Co+inhibitor<br />
 +
**[[5lyw]], [[5lyx]] - hMet-AP 2 (mutant) + Zn + inhibitor<br />
 +
**[[1r58]], [[1r5g]], [[1r5h]], [[5ji6]], [[5jhu]], [[5jfr]], [[5cls]], [[4z7m]], [[5jhu]], [[5jfr]], [[2ea2]], [[2ea4]], [[2ga2]], [[5lyw]] - hMet-AP 2 +Mn+inhibitor<br />
*Arginine aminopeptidase
*Arginine aminopeptidase
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**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''
**[[3ij3]] – Cyt-AP – ''Coxiella burnetii''
-
*Aminopeptidase 2
+
*Endoplasmic reticulum aminopeptidase
-
**[[3se6]] – hAPN<br />
+
**[[5j5e]] – hARTS-1 ERAP1 domain<br />
-
**[[4e36]] – hAPN + Zn
+
**[[3se6]] – hARTS-2<br />
 +
**[[4e36]] – hARTS-2 + Zn<br />
 +
**[[5k1v]], [[5j6s]] – hARTS-2 + Zn + inhibitor<br />
*Non-specific aminopeptidase
*Non-specific aminopeptidase
Line 291: Line 307:
**[[3n5i]] – SxBapA (mutant)<br />
**[[3n5i]] – SxBapA (mutant)<br />
**[[3n33]] – SxBapA + AEBSF<br />
**[[3n33]] – SxBapA + AEBSF<br />
-
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin
+
**[[3ndv]], [[3nfb]] – SxBapA + ampicillin<br />
 +
**[[5tzb]] - AP – ''Burkholderia''<br />
*M1 family aminopeptidase
*M1 family aminopeptidase

Revision as of 09:30, 13 March 2018

Bacterial leucine aminopeptidase complex with 8-hydroxyquinoline, glycerol, SCN, Zn+2 (magenta), Na+ (cyan) and Cl- (green) ions (PDB code 3vh9)

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3D Structures of Aminopeptidase

Updated on 13-March-2018

Additional Resources

For additional information, see:
Amino Acid Synthesis & Metabolism
Streptomyces griseus Aminopeptidase (SGAP)

References

  1. ↑ Taylor A. Aminopeptidases: structure and function. FASEB J. 1993 Feb 1;7(2):290-8. PMID:8440407
  2. ↑ Hanaya K, Suetsugu M, Saijo S, Yamato I, Aoki S. Potent inhibition of dinuclear zinc(II) peptidase, an aminopeptidase from Aeromonas proteolytica, by 8-quinolinol derivatives: inhibitor design based on Zn(2+) fluorophores, kinetic, and X-ray crystallographic study. J Biol Inorg Chem. 2012 Feb 5. PMID:22311113 doi:10.1007/s00775-012-0873-4

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, David Canner, Joel L. Sussman, Eran Hodis

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