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5fsc
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsc OCA], [http://pdbe.org/5fsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsc RCSB], [http://www.ebi.ac.uk/pdbsum/5fsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsc ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsc OCA], [http://pdbe.org/5fsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsc RCSB], [http://www.ebi.ac.uk/pdbsum/5fsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Innate immunity is the first line of defense against pathogens and predators. To initiate a response, it relies on the detection of invaders, where lectin-carbohydrate interactions play a major role. O-Methylated glycans were previously identified as non-self epitopes and conserved targets for defense effector proteins belonging to the tectonin superfamily. Here, we present two crystal structures of Tectonin 2 from the mushroom Laccaria bicolor in complex with methylated ligands, unraveling the molecular basis for this original specificity. Furthermore, they revealed the formation of a ball-shaped tetramer with 24 binding sites distributed at its surface, resembling a small virus capsid. Based on the crystal structures, a methylation recognition motif was identified and found in the sequence of many tectonins from bacteria to human. Our results support a key role of tectonins in innate defense based on a distinctive and conserved type of lectin-glycan interaction. | ||
| + | |||
| + | Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.,Sommer R, Makshakova ON, Wohlschlager T, Hutin S, Marsh M, Titz A, Kunzler M, Varrot A Structure. 2018 Mar 6;26(3):391-402.e4. doi: 10.1016/j.str.2018.01.003. Epub 2018, Feb 1. PMID:29398527<ref>PMID:29398527</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5fsc" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 06:47, 14 March 2018
Structure of tectonin 2 from Laccaria bicolor in complex with allyl- alpha_4-methyl-mannoside
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