1v0n

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[[Category: xylanase]]
[[Category: xylanase]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:46:49 2007''
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Revision as of 15:12, 5 November 2007

Image:1v0n.gif

1v0n, resolution 1.10Å

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XYLANASE XYN10A FROM STREPTOMYCES LIVIDANS IN COMPLEX WITH XYLOBIO-ISOFAGOMINE AT PH 7.5

Overview

The atomic resolution structures of xylobiose-derived isofagomine and, xylobiose-derived deoxynojirimycin in complex with the xylanase Xyn10A, from Streptomyces lividans reveal undistorted (4)C(1) chair conformed, sugars and, in the case of the deoxynojirimycin analogue, suggest unusual, pK(a) changes of the enzyme's catalytic machinery upon binding.

About this Structure

1V0N is a Single protein structure of sequence from Streptomyces lividans with EDO and IMD as ligands. Active as Endo-1,4-beta-xylanase, with EC number 3.2.1.8 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A., Gloster TM, Williams SJ, Roberts S, Tarling CA, Wicki J, Withers SG, Davies GJ, Chem Commun (Camb). 2004 Aug 21;(16):1794-5. Epub 2004 Jul 23. PMID:15306887

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