Apoptosis-inducing factor
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='450' side='right' caption='Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code [[4bur]])' scene='74/749463/Cv/1'> |
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | The AIF binding site contains the cofactor <scene name='74/749463/Cv/2'>FAD</scene> and 2 molecules of the reducing factor NADH<ref>PMID:24914854</ref>. Water molecules shown as red spheres. | ||
| + | *<scene name='74/749463/Cv/3'>1st NADH binding site</scene>. | ||
| + | *<scene name='74/749463/Cv/4'>2nd NADH binding site</scene>. | ||
| + | *<scene name='74/749463/Cv/5'>FAD/1st molecule NADF tunnel</scene>. | ||
| + | *<scene name='74/749463/Cv/6'>2nd NADH binding site in surface representation</scene>. | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of apoptosis-inducing factor | + | ==3D structures of apoptosis-inducing factor see CED-8 in [[Cell death protein]]== |
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D structures of apoptosis-inducing factor see CED-8 in Cell death protein
References
- ↑ Cande C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G. Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie. 2002 Feb-Mar;84(2-3):215-22. PMID:12022952
- ↑ Coughlan MT, Higgins GC, Nguyen TV, Penfold SA, Thallas-Bonke V, Tan SM, Ramm G, Van Bergen NJ, Henstridge DC, Sourris KC, Harcourt BE, Trounce IA, Robb PM, Laskowski A, McGee SL, Genders AJ, Walder K, Drew BG, Gregorevic P, Qian H, Thomas MC, Jerums G, Macisaac RJ, Skene A, Power DA, Ekinci EI, Wijeyeratne XW, Gallo LA, Herman-Edelstein M, Ryan MT, Cooper ME, Thorburn DR, Forbes JM. Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis. Diabetes. 2016 Apr;65(4):1085-98. doi: 10.2337/db15-0864. Epub 2016 Jan 28. PMID:26822084 doi:http://dx.doi.org/10.2337/db15-0864
- ↑ Ferreira P, Villanueva R, Martinez-Julvez M, Herguedas B, Marcuello C, Fernandez-Silva P, Cabon L, Hermoso JA, Lostao A, Susin SA, Medina M. Structural insights into the coenzyme mediated monomer-dimer transition of the pro-apoptotic apoptosis inducing factor. Biochemistry. 2014 Jul 1;53(25):4204-15. doi: 10.1021/bi500343r. Epub 2014 Jun, 20. PMID:24914854 doi:http://dx.doi.org/10.1021/bi500343r
