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| - | [[Image:2pdt.gif|left|200px]]<br /><applet load="2pdt" size="350" color="white" frame="true" align="right" spinBox="true" | + | #REDIRECT [[6cny]] This PDB entry is obsolete and replaced by 6cny |
| - | caption="2pdt, resolution 2.200Å" />
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| - | '''2.3 Angstrom Structure of Phosphodiesterase treated Vivid'''<br />
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| - | ==Overview==
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| - | The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).
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| - | ==About this Structure==
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| - | 2PDT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa] with <scene name='pdbligand=FAD:'>FAD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PDT OCA].
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| - | ==Reference==
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| - | Conformational switching in the fungal light sensor Vivid., Zoltowski BD, Schwerdtfeger C, Widom J, Loros JJ, Bilwes AM, Dunlap JC, Crane BR, Science. 2007 May 18;316(5827):1054-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17510367 17510367]
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| - | [[Category: Neurospora crassa]]
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| - | [[Category: Single protein]]
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| - | [[Category: Bilwes, A M.]]
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| - | [[Category: Crane, B R.]]
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| - | [[Category: Zoltowski, B D.]]
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| - | [[Category: FAD]]
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| - | [[Category: lov domain; flavin; photoreceptor; circadian clock]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:28:28 2008''
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