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6ckn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of an AF10 fragment== | |
| - | + | <StructureSection load='6ckn' size='340' side='right' caption='[[6ckn]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ckn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CKN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ckn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ckn OCA], [http://pdbe.org/6ckn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ckn RCSB], [http://www.ebi.ac.uk/pdbsum/6ckn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ckn ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN]] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | [[Category: | + | [[Category: Qin, S]] |
| - | [[Category: Structural | + | [[Category: Structural genomic]] |
| - | + | ||
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Sgc]] | ||
Revision as of 07:42, 21 March 2018
Crystal structure of an AF10 fragment
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Categories: Arrowsmith, C H | Bountra, C | Edwards, A M | Li, Y | Min, J | Qin, S | Structural genomic | Tempel, W | Dna binding protein | Sgc
