1v1j
From Proteopedia
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Revision as of 15:13, 5 November 2007
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CRYSTAL STRUCTURE OF TYPE II DEHYDROQUINTAE DEHYDRATASE FROM STREPTOMYCES COELICOLOR IN COMPLEX WITH 3-FLUORO
Overview
The fluoro analogue of the enolate intermediate in the reaction catalyzed, by type II dehydroquinases has been prepared from naturally occurring, (-)-quinic acid over seven steps and has been shown to be the most potent, inhibitor reported to date of the type II enzyme from Mycobacterium, tuberculosis.
About this Structure
1V1J is a Single protein structure of sequence from Streptomyces coelicolor with FA3 and TRS as ligands. Active as 3-dehydroquinate dehydratase, with EC number 4.2.1.10 Structure known Active Site: DHQ. Full crystallographic information is available from OCA.
Reference
(1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases., Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C, Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. PMID:15162210
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