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1uct

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Revision as of 08:55, 21 March 2018

Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)

Structural highlights

1uct is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[FCAR_HUMAN] Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs. In this work, we analyzed the crystal structure of the ectodomain of FcalphaRI and examined structure similarities between FcalphaRI and KIR2DL1, KIR2DL2 and LIR-1. Our data show that FcalphaRI, KIRs, and LIRs share a common hydrophobic core in their interdomain interface, and FcalphaRI is evolutionally closer to LIR than KIR.

Crystal structure of the ectodomain of human FcalphaRI.,Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:12783876^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ding Y, Xu G, Yang M, Yao M, Gao GF, Wang L, Zhang W, Rao Z. Crystal structure of the ectodomain of human FcalphaRI. J Biol Chem. 2003 Jul 25;278(30):27966-70. Epub 2003 Jun 3. PMID:12783876 doi:10.1074/jbc.C300223200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uct"

@@ Line 1: / Line 1: @@
 ==Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)==
 <StructureSection load='1uct' size='340' side='right' caption='[[1uct]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1uct]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UCT FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uct OCA], [http://pdbe.org/1uct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uct RCSB], [http://www.ebi.ac.uk/pdbsum/1uct PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uct OCA], [http://pdbe.org/1uct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uct RCSB], [http://www.ebi.ac.uk/pdbsum/1uct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uct ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 11: / Line 12: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1uct_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uc/1uct_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>

1uct

From Proteopedia

Revision as of 08:55, 21 March 2018

Crystal structure of the extracellular fragment of Fc alpha Receptor I (CD89)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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