Beta-lactamase
From Proteopedia
(Difference between revisions)
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**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> | ||
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br /> | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br /> | ||
| + | **[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br /> | ||
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | **[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | ||
**[[1li0]] - EcBlac A Tem-32 (mutant) <br /> | **[[1li0]] - EcBlac A Tem-32 (mutant) <br /> | ||
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**[[4id4]] – EcBlac/PaBlac Tem<br /> | **[[4id4]] – EcBlac/PaBlac Tem<br /> | ||
**[[3o3v]] – EcBlac peptidase domain<br /> | **[[3o3v]] – EcBlac peptidase domain<br /> | ||
| - | **[[1o7e]], [[1n4o]] – StmBlac A – ''Stenotrophonas maltophilia''<br /> | + | **[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br /> |
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br /> | **[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br /> | ||
**[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1<br /> | **[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1<br /> | ||
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**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | **[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br /> | ||
**[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''<br /> | **[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''<br /> | ||
| - | **[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br /> | + | **[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br /> |
**[[3zdj]], [[4b88]] – Blac – precambrian<br /> | **[[3zdj]], [[4b88]] – Blac – precambrian<br /> | ||
**[[4c6y]], [[4c75]], [[5fqm]] – Blac – synthetic<br /> | **[[4c6y]], [[4c75]], [[5fqm]] – Blac – synthetic<br /> | ||
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**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | **[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | ||
**[[5fa7]] - EcBlac A + inhibitor<br /> | **[[5fa7]] - EcBlac A + inhibitor<br /> | ||
| - | **[[5chm]], [[5chj]] – EcBlac FOX-4 + antibiotic<br /> | + | **[[5chm]], [[5chj]], [[5za2]] – EcBlac FOX-4 + antibiotic<br /> |
**[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br /> | **[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br /> | ||
**[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br /> | **[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br /> | ||
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**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | **[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br /> | ||
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]] - BlBlac A (mutant) + antibiotic<br /> | **[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]] - BlBlac A (mutant) + antibiotic<br /> | ||
| - | **[[4m3k]], [[4n1h]] - BlBlac A + antibody<br /> | + | **[[4m3k]], [[4n1h]], [[5lwf]] - BlBlac A + antibody<br /> |
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | **[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br /> | ||
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br /> | **[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br /> | ||
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**[[5l2f]] - AbBlac A + antibiotic<br /> | **[[5l2f]] - AbBlac A + antibiotic<br /> | ||
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br /> | **[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br /> | ||
| + | **[[5ne1]] - StmBlac A + boronic acid inhibitor <br /> | ||
| + | **[[5ne3]] - StmBlac A + antibiotic <br /> | ||
*Extended-spectrum β-lactamase class A | *Extended-spectrum β-lactamase class A | ||
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**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br /> | **[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br /> | ||
**[[4wz5]] – PaESBL Oxa-10 <br /> | **[[4wz5]] – PaESBL Oxa-10 <br /> | ||
| + | **[[5mmy]], [[5mnu]] – PaESBL Oxa-10 (mutant)<br /> | ||
**[[4yin]] – PaESBL Oxa-145 <br /> | **[[4yin]] – PaESBL Oxa-145 <br /> | ||
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br /> | **[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br /> | ||
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**[[4opr]], [[4opq]] - EcESBL Tem-94 (mutant)<br /> | **[[4opr]], [[4opq]] - EcESBL Tem-94 (mutant)<br /> | ||
**[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br /> | **[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br /> | ||
| - | **[[3hre]] - EcESBL Ctx-M-9 (mutant)<br /> | + | **[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br /> |
**[[4ua6]] – EcESBL Ctx-M-14 <br /> | **[[4ua6]] – EcESBL Ctx-M-14 <br /> | ||
| - | **[[1ylt]] - EcBlac A Ctx-M-14 (mutant)<br /> | + | **[[1ylt]], [[5vth]], [[5twd]] - EcBlac A Ctx-M-14 (mutant)<br /> |
**[[4hbt]] – EcESBL Ctx-M-15<br /> | **[[4hbt]] – EcESBL Ctx-M-15<br /> | ||
**[[1ylw]] - EcESBL Ctx-M-16<br /> | **[[1ylw]] - EcESBL Ctx-M-16<br /> | ||
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | **[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | ||
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br /> | **[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br /> | ||
| + | **[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br /> | ||
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcESBLToho-1 (mutant) <br /> | **[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcESBLToho-1 (mutant) <br /> | ||
**[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br /> | **[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br /> | ||
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**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br /> | **[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br /> | ||
**[[2qpn]] – KpESBL A GES-1<br /> | **[[2qpn]] – KpESBL A GES-1<br /> | ||
| + | **[[5gs8]] – SmESBL TLA-3 <br /> | ||
*Extended-spectrum β-lactamase class A binary complex | *Extended-spectrum β-lactamase class A binary complex | ||
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**[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br /> | **[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br /> | ||
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | **[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | ||
| - | **[[4xxr]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | + | **[[5vle]], [[5top]], [[5toy]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br /> |
| + | **[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | **[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br /> | ||
**[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> | **[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> | ||
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | **[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | ||
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br /> | **[[5g18]] - EcESBL Ctx-M-97 + substrate<br /> | ||
| + | **[[4oqh]] - EcESBL Tem-63 (mutant) + boronic acid inhibitor<br /> | ||
**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br /> | **[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br /> | ||
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br /> | **[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br /> | ||
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**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | **[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | **[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | ||
| + | **[[5x5g]] – SmESBL TLA-3 + inhibitor<br /> | ||
| + | **[[5gwa]] – SmESBL TLA-3 + antibiotic<br /> | ||
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip) | *β-lactamase class A complex with β-lactamase inhibitor protein (Blip) | ||
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**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | **[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | ||
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | **[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | ||
| - | **[[2fhx]], [[4bp0]] - PaBlac B Spm-1<br /> | ||
**[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | **[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | ||
**[[2x02]] - PaBlac Oxa-10<br /> | **[[2x02]] - PaBlac Oxa-10<br /> | ||
| - | **[[4uam]] - PaBlac Imp-1 <br /> | + | **[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br /> |
| - | **[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br /> | + | **[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br /> |
**[[5b3r]] - PaBlac Imp-18 <br /> | **[[5b3r]] - PaBlac Imp-18 <br /> | ||
**[[5ev6]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> | **[[5ev6]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> | ||
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**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br /> | **[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br /> | ||
**[[3r2u]] – SaBlac B<br /> | **[[3r2u]] – SaBlac B<br /> | ||
| - | **[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]] - KpBlac B Ndm-1<br /> | + | **[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]] - KpBlac B Ndm-1<br /> |
| - | **[[3srx]] - KpBlac B Ndm-1 (Cd) <br /> | + | **[[3srx]], [[6ex7]] - KpBlac B Ndm-1 (Cd) <br /> |
**[[4h0d]] - KpBlac B Ndm-1 (Mn)<br /> | **[[4h0d]] - KpBlac B Ndm-1 (Mn)<br /> | ||
| + | **[[5xp6]], [[5n0i]], [[5k4k]], [[5k4m]], [[5k4n]], [[5jqj]] - KpBlac B Ndm-1 (Zn)<br /> | ||
| + | **[[5xp9]] - KpBlac B Ndm-1 (Bi)<br /> | ||
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br /> | **[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br /> | ||
| + | **[[5wig]] - KpBlac B Ndm-4 (Zn)<br /> | ||
| + | **[[5n5g]] - PaBlac B Vim-1<br /> | ||
**[[3s0z]] - EcBlac B Ndm-1<br /> | **[[3s0z]] - EcBlac B Ndm-1<br /> | ||
**[[4tz9]] - EcBlac B Ndm-3<br /> | **[[4tz9]] - EcBlac B Ndm-3<br /> | ||
**[[4tyf]] - EcBlac B Ndm-4<br /> | **[[4tyf]] - EcBlac B Ndm-4<br /> | ||
**[[4tzf]] - EcBlac B Ndm-8<br /> | **[[4tzf]] - EcBlac B Ndm-8<br /> | ||
| + | **[[5wih]] - EcBlac B Ndm-12<br /> | ||
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | **[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br /> | ||
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | **[[3sd9]] – SfBlac B - ''Serratia fonticola''<br /> | ||
**[[4ubq]] - AbBlac Imp-2 <br /> | **[[4ubq]] - AbBlac Imp-2 <br /> | ||
| - | **[[ | + | **[[5mmd]] - AbBlac Tmb-1 <br /> |
**[[5a87]] - KpBlac B Vim-5<br /> | **[[5a87]] - KpBlac B Vim-5<br /> | ||
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br /> | **[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br /> | ||
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**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br /> | **[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br /> | ||
**[[1jt1]] – FgBlac + captopril <br /> | **[[1jt1]] – FgBlac + captopril <br /> | ||
| - | **[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]] - PaBlac B Imp-1+ inhibitor<br /> | + | **[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br /> |
| - | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]] - PaBlac B Vim-2 + inhibitor<br /> | + | **[[5n5h]] - PaBlac B Vim-1 + inhibitor<br /> |
| - | **[[4s2o]] - PaBlac Oxa-10 + antibiotic<br /> | + | **[[5n5i]] - PaBlac B Vim-1 + antibiotic<br /> |
| + | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]] - PaBlac B Vim-2 + inhibitor<br /> | ||
| + | **[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br /> | ||
| + | **[[5mm9]] - PaBlac B Vim-17 + inhibitor<br /> | ||
| + | **[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br /> | ||
**[[5fq9]] - PaBlac Oxa-10 + inhibitor<br /> | **[[5fq9]] - PaBlac Oxa-10 + inhibitor<br /> | ||
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | **[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br /> | ||
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**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | **[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | ||
**[[5wcm]] – BjBlac B + inhibitor<br /> | **[[5wcm]] – BjBlac B + inhibitor<br /> | ||
| - | **[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]] - BcBlac B + inhibitor<br /> | + | **[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]], [[5jmx]] - BcBlac B + inhibitor<br /> |
| + | **[[5ew0]] - SfBlac B + inhibitor<br /> | ||
**[[3q6v]] – SfBlac B + glycerol <br /> | **[[3q6v]] – SfBlac B + glycerol <br /> | ||
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br /> | **[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br /> | ||
| - | **[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]] – KpBlac B Ndm-1+ inhibitor<br /> | + | **[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]] – KpBlac B Ndm-1+ inhibitor<br /> |
| + | **[[5nai]] – KpBlac B Vim-5 + inhibitor<br /> | ||
| + | **[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypin] – EcBlac B Ndm-1 + antibiotic<br /> | ||
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | **[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | ||
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br /> | **[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br /> | ||
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*'''β-lactamase class C''' | *'''β-lactamase class C''' | ||
| - | **[[5f1g]] – EcBlac C<br /> | + | **[[5f1g]], [[5ggw]] – EcBlac C<br /> |
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | **[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br /> | ||
| - | **[[1zkj]], [[5f1f]] – Blac C – ''Enterobacter aerogenes''<br /> | + | **[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – Blac C – ''Enterobacter aerogenes''<br /> |
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | **[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | ||
**[[3w8k]] – KpBlac C<br /> | **[[3w8k]] – KpBlac C<br /> | ||
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**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br /> | **[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br /> | ||
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br /> | **[[1s6r]] - EncBlac C+ boronic acid inhibitor<br /> | ||
| - | **[[1rgz]] - EncBlac C + antibiotic<br /> | + | **[[1rgz]], [[5xhr]] - EncBlac C + antibiotic<br /> |
**[1rgy]] - CfBlac C + antibiotic <br /> | **[1rgy]] - CfBlac C + antibiotic <br /> | ||
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | **[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br /> | ||
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**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br /> | **[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br /> | ||
**[[4ooy]] - PaBlac C + antibiotic<br /> | **[[4ooy]] - PaBlac C + antibiotic<br /> | ||
| - | **[[4u0x]] - AbBlac C Adc-7 + boronic acid inhibitor <br /> | + | **[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]] - AbBlac C Adc-7 + boronic acid inhibitor <br /> |
*'''β-lactamase class D''' | *'''β-lactamase class D''' | ||
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**[[4zdx]] - AbBlac D Oxa-51<br /> | **[[4zdx]] - AbBlac D Oxa-51<br /> | ||
**[[4y0o]] - AbBlac D Oxa-58<br /> | **[[4y0o]] - AbBlac D Oxa-58<br /> | ||
| - | **[[4s2l]] - EncBlac D Oxa-163<br /> | + | **[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br /> |
**[[5e2f]] – Blac D – ''Bacillus subtilis''<br /> | **[[5e2f]] – Blac D – ''Bacillus subtilis''<br /> | ||
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | **[[4ied]] – Blac – ''Fusobacterium nucleatum''<br /> | ||
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**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | **[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | ||
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | **[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | ||
| + | **[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br /> | ||
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | **[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | ||
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | **[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | ||
| Line 300: | Line 322: | ||
[[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | [[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | ||
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br /> | **[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br /> | ||
| - | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]] - KpBlac D Oxa-48 + inhibitor<br /> | + | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]] [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]] - KpBlac D Oxa-48 + inhibitor<br /> |
*'''AmpC β-lactamase''' | *'''AmpC β-lactamase''' | ||
| - | **[[1ke4]], [[2bls]], [[2zj9]], [[3bls]] – EcBlac<br /> | + | **[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]] – EcBlac<br /> |
| - | **[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]] - EcBlac (mutant) | + | **[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant) |
**[[1fcn]] – EcBlac (mutant) + substrate<br /> | **[[1fcn]] – EcBlac (mutant) + substrate<br /> | ||
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br /> | **[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br /> | ||
| Line 326: | Line 348: | ||
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br /> | **[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br /> | ||
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br /> | **[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br /> | ||
| - | **[[3rxw]], [[3rxx]], [[2ov5]] – KpBlac Kpc<br /> | + | **[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br /> |
**[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | **[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | ||
**[[4zbe]] - KpBlac Kpc-2 + inhibitor<br /> | **[[4zbe]] - KpBlac Kpc-2 + inhibitor<br /> | ||
| + | **[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br /> | ||
| + | **[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br /> | ||
**[[4eqi]] – SfBlac Sfc-1<br /> | **[[4eqi]] – SfBlac Sfc-1<br /> | ||
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br /> | **[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br /> | ||
| Line 335: | Line 359: | ||
**[[4oh0]], [[4z9q]] - AbBlac OXA-58 <br /> | **[[4oh0]], [[4z9q]] - AbBlac OXA-58 <br /> | ||
**[[5boh]] - AbBlac OXA-58 (mutant)<br /> | **[[5boh]] - AbBlac OXA-58 (mutant)<br /> | ||
| + | **[[5iy2]] - AbBlac OXA-143 <br /> | ||
**[[1bue]] – EncBlac<br /> | **[[1bue]] – EncBlac<br /> | ||
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br /> | **[[4tze]], [[4tzb]] - EcBlac Ndm-5<br /> | ||
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br /> | **[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br /> | ||
| + | **[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br /> | ||
*'''Other β-lactamase''' | *'''Other β-lactamase''' | ||
| Line 348: | Line 374: | ||
**[[1dy6]] – SmBlac Sme-1<br /> | **[[1dy6]] – SmBlac Sme-1<br /> | ||
**[[1fr1]], [[1fr6]] – CfBlac <br /> | **[[1fr1]], [[1fr6]] – CfBlac <br /> | ||
| - | **[[1i2s]] – BlBlac<br /> | + | **[[1i2s]], [[4blm]] – BlBlac<br /> |
| - | **[[2gdn]], [[3zhh]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | + | **[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br /> |
**[[4whi]] – MtBlac C terminal<br /> | **[[4whi]] – MtBlac C terminal<br /> | ||
**[[4jlf]] - MtBlac (mutant)<br /> | **[[4jlf]] - MtBlac (mutant)<br /> | ||
**[[2jc7]], [[3g4p]] – AbBlac <br /> | **[[2jc7]], [[3g4p]] – AbBlac <br /> | ||
| - | **[[3byd]] – | + | **[[3byd]] – KoBlac <br /> |
**[[3i7j]] – Blac – ''Mycobacterium bovis''<br /> | **[[3i7j]] – Blac – ''Mycobacterium bovis''<br /> | ||
**[[3lez]] – Blac – ''Oceanobacter iheyensis''<br /> | **[[3lez]] – Blac – ''Oceanobacter iheyensis''<br /> | ||
**[[3p09]] – Blac – ''Francisella tularensis''<br /> | **[[3p09]] – Blac – ''Francisella tularensis''<br /> | ||
| - | **[[4blm]] - BlBlac<br /> | ||
**[[4ewf]] – Blac – ''Sphaerobacter thermophilus''<br /> | **[[4ewf]] – Blac – ''Sphaerobacter thermophilus''<br /> | ||
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br /> | **[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br /> | ||
| Line 363: | Line 388: | ||
**[[5ihv]] – Blac – ''Burkholderia ambifaria''<br /> | **[[5ihv]] – Blac – ''Burkholderia ambifaria''<br /> | ||
**[[5hx9]], [[5hw3]] – Blac – ''Burkholderia vietnamiensis''<br /> | **[[5hx9]], [[5hw3]] – Blac – ''Burkholderia vietnamiensis''<br /> | ||
| + | **[[5vpq]] – Blac – ''Burkholderia phymatum''<br /> | ||
**[[5evl]] – Blac – ''Chromobacterterium violaceum''<br /> | **[[5evl]] – Blac – ''Chromobacterterium violaceum''<br /> | ||
**[[5e43]] – Blac – ''Streptoporangium roseum''<br /> | **[[5e43]] – Blac – ''Streptoporangium roseum''<br /> | ||
| Line 368: | Line 394: | ||
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | **[[4k0w]] – AbBlac Oxa-23 (mutant)<br /> | ||
**[[4k0x]] – AbBlac Oxa-23 <br /> | **[[4k0x]] – AbBlac Oxa-23 <br /> | ||
| + | **[[5oe0]] – KpBlac Oxa-181 <br /> | ||
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | **[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | ||
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | **[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | ||
Revision as of 10:14, 26 March 2018
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3D Structures of Beta-lactamase
Updated on 26-March-2018
4mll - KpBlac D Oxa-1 + antibiotic
References
- ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
