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6fv0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of torsinA== | |
| + | <StructureSection load='6fv0' size='340' side='right' caption='[[6fv0]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6fv0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FV0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fv0 OCA], [http://pdbe.org/6fv0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fv0 RCSB], [http://www.ebi.ac.uk/pdbsum/6fv0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fv0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Kinesin-mediated cargo transport is required for many cellular functions and plays a key role in pathological processes. Structural information on how kinesins recognize their cargoes is required for a molecular understanding of this fundamental and ubiquitous process. Here, we present the crystal structure of the tetratricopeptide repeat of kinesin light chain 2 in complex with a cargo peptide harboring a 'tryptophan-acidic' motif derived from SKIP, a critical host determinant in Salmonella pathogenesis and a regulator of lysosomal positioning. Structural data together with biophysical, biochemical, and cellular assays allow us to propose a framework for intracellular transport based on the binding by kinesin-1 of W-acidic cargo motifs through a combination of electrostatic interactions and sequence-specific elements, providing direct molecular evidence of the mechanisms for kinesin-1:cargo recognition. | ||
| - | + | Structural Basis For Kinesin-1:Cargo Recognition.,Pernigo S, Lamprecht A, Steiner RA, Dodding MP Science. 2013 Mar 21. PMID:23519214<ref>PMID:23519214</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 6fv0" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dodding, M P]] | ||
[[Category: Pernigo, S]] | [[Category: Pernigo, S]] | ||
| + | [[Category: Steiner, R A]] | ||
| + | [[Category: Cargo recognition]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Nanobody]] | ||
| + | [[Category: Protein complex]] | ||
Current revision
Crystal structure of the TPR domain of KLC1 in complex with the C-terminal peptide of torsinA
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