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1gk5

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Revision as of 06:49, 28 March 2018

Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor

Structural highlights

1gk5 is a 1 chain structure with sequence from Human. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	TGFA (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[EGF_MOUSE] EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The solution structure of the growth factor chimera mEGF/TGFalpha44-50 has been determined using an extended version of the dyana procedure for calculating structures from NMR data. The backbone fold and preferred orientation of the domains of the chimera are similar to those found in previous studies of EGF structures, and several H-bonds used as input constraints in those studies were found independently in the chimera. This shows that the modified activity of the chimera does not result from a major structural change. However, the improved precision of the structure presented here allows the origin of some unusual chemical shifts found in all of these compounds to be explained, as well as the results obtained from some site-specific mutants. Further studies of the properties of this chimeric growth factor should help to elucidate the mechanism(s) of hetero- and homodimerization of the c-erbB receptors.

Solution structure of the mEGF/TGFalpha44-50 chimeric growth factor.,Chamberlin SG, Brennan L, Puddicombe SM, Davies DE, Turner DL Eur J Biochem. 2001 Dec;268(23):6247-55. PMID:11733021^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chamberlin SG, Brennan L, Puddicombe SM, Davies DE, Turner DL. Solution structure of the mEGF/TGFalpha44-50 chimeric growth factor. Eur J Biochem. 2001 Dec;268(23):6247-55. PMID:11733021

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gk5"

@@ Line 3: / Line 3: @@
 <StructureSection load='1gk5' size='340' side='right' caption='[[1gk5]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1gk5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GK5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1gk5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GK5 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gk5 OCA], [http://pdbe.org/1gk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gk5 RCSB], [http://www.ebi.ac.uk/pdbsum/1gk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gk5 ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TGFA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gk5 OCA], [http://pdbe.org/1gk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gk5 RCSB], [http://www.ebi.ac.uk/pdbsum/1gk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gk5 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 12: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gk5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gk5_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 34: / Line 35: @@
 __TOC__
 </StructureSection>
-[[Category: Mus musculus]]
+[[Category: Human]]
 [[Category: Brennan, L]]
 [[Category: Chamberlin, S G]]

1gk5

From Proteopedia

Revision as of 06:49, 28 March 2018

Solution Structure the mEGF/TGFalpha44-50 chimeric growth factor

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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