2g7c
From Proteopedia
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|PDB= 2g7c |SIZE=350|CAPTION= <scene name='initialview01'>2g7c</scene>, resolution 2.0Å | |PDB= 2g7c |SIZE=350|CAPTION= <scene name='initialview01'>2g7c</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | + | |LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= toxA, tcdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 Clostridium difficile]) | |GENE= toxA, tcdA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1496 Clostridium difficile]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2f6e|2F6E]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g7c OCA], [http://www.ebi.ac.uk/pdbsum/2g7c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g7c RCSB]</span> | ||
}} | }} | ||
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[[Category: Palcic, M M.]] | [[Category: Palcic, M M.]] | ||
[[Category: Rupnik, M.]] | [[Category: Rupnik, M.]] | ||
| - | [[Category: GOL]] | ||
[[Category: bacterial toxin]] | [[Category: bacterial toxin]] | ||
[[Category: linear b trisaccharide]] | [[Category: linear b trisaccharide]] | ||
[[Category: protein-carbohydrate complex]] | [[Category: protein-carbohydrate complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:12:50 2008'' |
Revision as of 00:12, 31 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | toxA, tcdA (Clostridium difficile) | ||||||
| Related: | 2F6E
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Clostridium difficile Toxin A Fragment Bound to aGal(1,3)bGal(1,4)bGlcNAc
Overview
Clostridium difficile TcdA is a large toxin that binds carbohydrates on intestinal epithelial cells. A 2-A resolution cocrystal structure reveals two molecules of alpha-Gal-(1,3)-beta-Gal-(1,4)-beta-GlcNAcO(CH(2))(8)CO(2)CH(3) binding in an extended conformation to TcdA. Residues forming key contacts with the trisaccharides are conserved in all seven putative binding sites in TcdA, suggesting a mode of multivalent binding that may be exploited for the rational design of novel therapeutics.
About this Structure
2G7C is a Single protein structure of sequence from Clostridium difficile. Full crystallographic information is available from OCA.
Reference
Carbohydrate recognition by Clostridium difficile toxin A., Greco A, Ho JG, Lin SJ, Palcic MM, Rupnik M, Ng KK, Nat Struct Mol Biol. 2006 May;13(5):460-1. Epub 2006 Apr 16. PMID:16622409
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