Sandbox1qu7
From Proteopedia
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== Disease and Relevance == | == Disease and Relevance == | ||
| - | If we can understand<ref>PMID: 25834953</ref> how the bacteria moves we might be able to make antibiotics that can target those specific control sites and prevent diseases by halting their search for attractant molecules. | + | If we can understand<ref name="Falke">PMID: 25834953</ref> how the bacteria moves<ref name="Falke" /> we might be able to make antibiotics that can target those specific control sites and prevent diseases by halting their search for attractant molecules. |
The chemoreceptors Escherichia coli and Salmonella typhimurium are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis. It proposes that strong helix packing stabilizes the receptor. | The chemoreceptors Escherichia coli and Salmonella typhimurium are stable and ultrasensitive molecules with coupling proteins, CheW and CheA attached at the bottom. A ligand bound can stimulate change through the kinase control model as a response. Among the 3 kinase control regulations, CheA and CheW binding is done through stable spatial clustering-leading to the YinYang Hypothesis. It proposes that strong helix packing stabilizes the receptor. | ||
Revision as of 20:18, 29 March 2018
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References
- ↑ 1.0 1.1 Parkinson JS, Hazelbauer GL, Falke JJ. Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update. Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub, 2015 Mar 30. PMID:25834953 doi:http://dx.doi.org/10.1016/j.tim.2015.03.003
