This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Vpr protein
From Proteopedia
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
| - | '''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia|AIDS}}) disease, including regulation the HIV-1 pre-integration complex nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of infect cells by blockade at G2 phase, when the viral | + | '''Vpr protein''' (Vpr) or '''viral protein R''' is a 96 amino acid protein which encoded by the human Immunodeficiency virus type 1 ([[HIV-1]]). Vpr has several roles in the progression of acquired immunodeficiency syndrome ({{Wikipedia|AIDS}}) disease, including regulation the HIV-1 pre-integration complex ({{Wikipedia|Pre-integration_complex}}) nuclear import and virus replication in non-dividing macrophages<ref>PMID:12614620</ref>. Moreover, Vpr prevents mitosis of dividing infect cells by blockade at G2 phase, when the viral promoter is more active, and induced apoptosis of these cells in G1 and M phase<ref>PMID:28075409</ref>. |
For details see [[HIV and accessory proteins]]. | For details see [[HIV and accessory proteins]]. | ||
Revision as of 13:04, 3 April 2018
| |||||||||||
3D Structures of Vpr protein
Updated on 03-April-2018
1m8l – Vpr - NMR - HIV-1
1esx - synthetic Vpr - NMR - HIV-1
5jk7 – Vpr + DDB1 + DCAF-1 + UNG2 – X-ray solution - HIV-1
1x9v – Dimeric structure of the Vpr C-terminal domain - NMR
1vpc - C-terminal domain of Vpr - NMR - HIV-1
1fi0 - Vpr residues 13-33 in micelles - NMR - HIV-1
1bde - NMR solution of Vpr peptides connected to cell cycle arrest and nuclear provirus transfer
5b56 - Importin subunit alpha-1 + Vpr C-terminal domain - crystallographic analysis
1kzs, 1kzt, 1kzv - Vpr residues 34-51 - NMR - HIV-1
1dsj - Vpr residues 50-75 - NMR - HIV-1
1ceu - Vpr N-terminal domain - NMR - HIV-1
1dsk - Vpr residues 59-86 - NMR - HIV-1
4u1s - HLA-I + Beta-2-microglobulin + Vpr protein - X-ray diffraction
References
- ↑ Morellet N, Bouaziz S, Petitjean P, Roques BP. NMR structure of the HIV-1 regulatory protein VPR. J Mol Biol. 2003 Mar 14;327(1):215-27. PMID:12614620
- ↑ Gonzalez ME. The HIV-1 Vpr Protein: A Multifaceted Target for Therapeutic Intervention. Int J Mol Sci. 2017 Jan 10;18(1). pii: ijms18010126. doi: 10.3390/ijms18010126. PMID:28075409 doi:http://dx.doi.org/10.3390/ijms18010126
