1w3c
From Proteopedia
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Revision as of 15:18, 5 November 2007
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CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS3 PROTEASE IN COMPLEX WITH A PEPTIDOMIMETIC INHIBITOR
Overview
The design of a series of peptidomimetic inhibitors of the hepatitis C, virus NS3 protease is described. These inhibitors feature an, indoline-2-carboxamide as a novel heterocyclic replacement for the P3, amino acid residue and N-terminal capping group of tripeptide based, inhibitors. The crystal structure of the ternary NS3/NS4A/inhibitor, complex for the most active molecule in this series highlights its, suitability as an N-terminal capping group of a dipeptide inhibitor of the, NS3 protease.
About this Structure
1W3C is a Single protein structure of sequence from Viruses with DN1 and DN2 as ligands. Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease., Ontoria JM, Di Marco S, Conte I, Di Francesco ME, Gardelli C, Koch U, Matassa VG, Poma M, Steinkuhler C, Volpari C, Harper S, J Med Chem. 2004 Dec 16;47(26):6443-6. PMID:15588076
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