5xj4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex structure of durvalumab-scFv/PD-L1== | |
| - | + | <StructureSection load='5xj4' size='340' side='right' caption='[[5xj4]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xj4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xj3|5xj3]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xj4 OCA], [http://pdbe.org/5xj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xj4 RCSB], [http://www.ebi.ac.uk/pdbsum/5xj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xj4 ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chai, Y]] | [[Category: Chai, Y]] | ||
| + | [[Category: Gao, G F]] | ||
[[Category: Liu, K]] | [[Category: Liu, K]] | ||
[[Category: Qi, J]] | [[Category: Qi, J]] | ||
| + | [[Category: Tan, S]] | ||
| + | [[Category: Complex structure]] | ||
| + | [[Category: Durvalumab]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Pd-l1]] | ||
Revision as of 05:28, 25 April 2018
Complex structure of durvalumab-scFv/PD-L1
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Categories: Chai, Y | Gao, G F | Liu, K | Qi, J | Tan, S | Complex structure | Durvalumab | Immune system | Pd-l1
