DNA methyltransferase

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Line 46: Line 46:
**[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br />
**[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br />
-
**[[4bhb]], [[4bhc]] - O6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br />
+
**[[4bhb]], [[4bhc]], [[4wxd]], [[4wxc]] - MtO6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br />
 +
**[[4wx9]] - MtO6-methylguanine DNMT (mutant) + modified DNA<br />
 +
**[[4zyg]], [[4zye]] - O6-methylguanine DNMT – ''Sulfolobus solfataricus''<br />
 +
**[[5llq]], [[4zyh]] - O6-methylguanine DNMT (mutant) <br />
 +
**[[4zyd]] - O6-methylguanine DNMT (mutant) + modified DNA<br />
*Methylcytosine DNMT
*Methylcytosine DNMT
Line 60: Line 64:
**[[1g55]] - h-cytosine DNMT2 (mutant)<br />
**[[1g55]] - h-cytosine DNMT2 (mutant)<br />
**[[3qkj]] - h-cytosine DNMT 3β<br />
**[[3qkj]] - h-cytosine DNMT 3β<br />
-
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse
 
**[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH
**[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH
Line 68: Line 71:
**[[5ciu]] - h-cytosine DNMT residues 206-355 + histone H3.2<br />
**[[5ciu]] - h-cytosine DNMT residues 206-355 + histone H3.2<br />
**[[4yoc]] - h-cytosine DNMT residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
**[[4yoc]] - h-cytosine DNMT residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
 +
**[[4z97]], [[4z96]] - h-cytosine DNMT residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br />
 +
**[[5ydr]] - h-cytosine DNMT RFTS domain residues 351-599 + ubiquitin<br />
 +
**[[5wvo]] - h-cytosine DNMT RFTS domain + ubiquitin + histone H3.1<br />
**[[4wxx]] - h-cytosine DNMT residues 351-1600 + SAH<br />
**[[4wxx]] - h-cytosine DNMT residues 351-1600 + SAH<br />
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
 +
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
 +
**[[6f57]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
-
 
+
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
 +
**[[5wy1]] - m-cytosine DNMT (mutant) <br />
 +
**[[5guv]], [[5gut]] - m-cytosine DNMT residues 731-1600 (mutant) <br />
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA

Revision as of 09:09, 30 April 2018

Adenine DNMT complex with SAM and Cl- ion (PDB code 1nw5).

Drag the structure with the mouse to rotate

3D Structures of DNA methyltransferase

Updated on 30-April-2018

References

  1. Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
  2. Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
  3. Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
  4. Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492

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Michal Harel, Alexander Berchansky

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