This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
DNA methyltransferase
From Proteopedia
(Difference between revisions)
| Line 46: | Line 46: | ||
**[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br /> | **[[2kif]], [[2kim]] - O6-methylguanine DNMT – ''Vibrio parahaemolyticus'' - NMR<br /> | ||
| - | **[[4bhb]], [[4bhc]] - | + | **[[4bhb]], [[4bhc]], [[4wxd]], [[4wxc]] - MtO6-methylguanine DNMT (mutant) – ''Mycobacterium tuberculosis''<br /> |
| + | **[[4wx9]] - MtO6-methylguanine DNMT (mutant) + modified DNA<br /> | ||
| + | **[[4zyg]], [[4zye]] - O6-methylguanine DNMT – ''Sulfolobus solfataricus''<br /> | ||
| + | **[[5llq]], [[4zyh]] - O6-methylguanine DNMT (mutant) <br /> | ||
| + | **[[4zyd]] - O6-methylguanine DNMT (mutant) + modified DNA<br /> | ||
*Methylcytosine DNMT | *Methylcytosine DNMT | ||
| Line 60: | Line 64: | ||
**[[1g55]] - h-cytosine DNMT2 (mutant)<br /> | **[[1g55]] - h-cytosine DNMT2 (mutant)<br /> | ||
**[[3qkj]] - h-cytosine DNMT 3β<br /> | **[[3qkj]] - h-cytosine DNMT 3β<br /> | ||
| - | **[[3av4]], [[1khc]] - m-cytosine DNMT – mouse | ||
**[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH | **[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH | ||
| Line 68: | Line 71: | ||
**[[5ciu]] - h-cytosine DNMT residues 206-355 + histone H3.2<br /> | **[[5ciu]] - h-cytosine DNMT residues 206-355 + histone H3.2<br /> | ||
**[[4yoc]] - h-cytosine DNMT residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br /> | **[[4yoc]] - h-cytosine DNMT residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br /> | ||
| + | **[[4z97]], [[4z96]] - h-cytosine DNMT residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br /> | ||
| + | **[[5ydr]] - h-cytosine DNMT RFTS domain residues 351-599 + ubiquitin<br /> | ||
| + | **[[5wvo]] - h-cytosine DNMT RFTS domain + ubiquitin + histone H3.1<br /> | ||
**[[4wxx]] - h-cytosine DNMT residues 351-1600 + SAH<br /> | **[[4wxx]] - h-cytosine DNMT residues 351-1600 + SAH<br /> | ||
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br /> | **[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br /> | ||
| + | **[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | ||
| + | **[[6f57]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br /> | ||
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br /> | **[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br /> | ||
| - | + | **[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br /> | |
| + | **[[5wy1]] - m-cytosine DNMT (mutant) <br /> | ||
| + | **[[5guv]], [[5gut]] - m-cytosine DNMT residues 731-1600 (mutant) <br /> | ||
**[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA | **[[3pt6]], [[3pt9]], [[4da4]] – m-cytosine DNMT + DNA | ||
Revision as of 09:09, 30 April 2018
| |||||||||||
3D Structures of DNA methyltransferase
Updated on 30-April-2018
References
- ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
- ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
- ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
- ↑ Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492
