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| - | [[Image:1rid.gif|left|200px]]<br /><applet load="1rid" size="350" color="white" frame="true" align="right" spinBox="true"
| + | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1rid was removed. |
| - | caption="1rid, resolution 2.1Å" />
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| - | '''Vaccinia Complement Protein in Complex with Heparin'''<br /> | + | |
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| - | ==Overview==
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| - | Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
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| - | ==About this Structure==
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| - | 1RID is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
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| - | ==Reference==
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| - | Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15178763 15178763]
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| - | [[Category: Single protein]]
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| - | [[Category: Vaccinia virus]]
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| - | [[Category: Ganesh, V K.]]
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| - | [[Category: Kotwal, G J.]]
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| - | [[Category: Murthy, K H.M.]]
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| - | [[Category: Smith, S A.]]
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| - | [[Category: complement]]
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| - | [[Category: regulation]]
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| - | [[Category: scr]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:51:11 2008''
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Current revision
For additional information see 2009, December: at Retractions and Fraud.</br>REMOVED: The PDB entry 1rid was removed.
