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| - | [[Image:1rid.gif|left|200px]]
| + | <span style='background-color: yellow;'>For additional information see '''2009, December:''' at [[Retractions and Fraud]].</span></br>REMOVED: The PDB entry 1rid was removed. |
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| - | {{Structure
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| - | |PDB= 1rid |SIZE=350|CAPTION= <scene name='initialview01'>1rid</scene>, resolution 2.1Å
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| - | |SITE=
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| - | |LIGAND= <scene name='pdbligand=IDS:O2-SULFO-GLUCURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>
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| - | |ACTIVITY=
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| - | |GENE= C3L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10245 Vaccinia virus])
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| - | |DOMAIN=
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| - | |RELATEDENTRY=[[1g40|1G40]], [[1g44|1G44]]
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| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rid OCA], [http://www.ebi.ac.uk/pdbsum/1rid PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rid RCSB]</span>
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| - | }}
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| - | '''Vaccinia Complement Protein in Complex with Heparin'''
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| - | ==Overview==
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| - | Vaccinia virus complement control protein (VCP), a homolog of the regulators of the complement activation family of proteins, inhibits complement activation through mechanisms similar to human fluid-phase complement regulators factor H and C4b-binding protein. VCP has a heparin-binding activity that assists vaccinia in host interactions. Interaction with cell-surface polyanions like heparin is centrally important in the functioning of fluid-phase complement regulators and is the basis of host-target discrimination by the alternative pathway. We report the structure of VCP in complex with a heparin decasaccharide, which reveals changes in VCP that might be pertinent to complement regulation. Properties that VCP shares with fluid-phase complement regulators suggest that such conformational changes may be of relevance in the functioning of other complement regulators. Additionally, comparison of VCP-heparin interactions with potentially similar interactions in factor H might enable understanding of the structural basis of familial hemolytic uremic syndrome, attributed to mutational disruption of heparin and C3b binding by factor H.
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| - | ==About this Structure==
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| - | 1RID is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RID OCA].
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| - | ==Reference==
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| - | Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation., Ganesh VK, Smith SA, Kotwal GJ, Murthy KH, Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8924-9. Epub 2004 Jun 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15178763 15178763]
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| - | [[Category: Single protein]]
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| - | [[Category: Vaccinia virus]]
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| - | [[Category: Ganesh, V K.]]
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| - | [[Category: Kotwal, G J.]]
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| - | [[Category: Murthy, K H.M.]]
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| - | [[Category: Smith, S A.]]
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| - | [[Category: complement]]
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| - | [[Category: regulation]]
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| - | [[Category: scr]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:28:34 2008''
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