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6byk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide== | |
| - | + | <StructureSection load='6byk' size='340' side='right' caption='[[6byk]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6byk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BYK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6byk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6byk OCA], [http://pdbe.org/6byk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6byk RCSB], [http://www.ebi.ac.uk/pdbsum/6byk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6byk ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/1433B_HUMAN 1433B_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.<ref>PMID:17717073</ref> <ref>PMID:19592491</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Schumacher, M A]] | ||
| + | [[Category: 14-3-3]] | ||
| + | [[Category: O-glcnac peptide]] | ||
| + | [[Category: Oga]] | ||
| + | [[Category: Ogt]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 06:16, 9 May 2018
Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide
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