Enoyl-CoA hydratase

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**[[2ppy]], [[2ej5]], [[2pbp]], [[2qq3]] – ECH – ''Geobacillus kaustophilus''<br />
**[[2ppy]], [[2ej5]], [[2pbp]], [[2qq3]] – ECH – ''Geobacillus kaustophilus''<br />
**[[3lke]] – ECH – ''Bacillus halodurans''<br />
**[[3lke]] – ECH – ''Bacillus halodurans''<br />
-
**[[3myb]], [[3njb]], [[3njd]], [[3pe8]], [[4qfe]], [[5e0n]] – ECH – ''Mycobacterium smegmatis''<br />
+
**[[3myb]], [[3njb]], [[3njd]], [[3pe8]], [[4qfe]], [[5e0n]], [[3ome]] – ECH – ''Mycobacterium smegmatis''<br />
-
**[[3oc7]], [[3p85]], [[3q1t]], [[3qyr]], [[4lk5]] – MaECH – ''Mycobacterium avium''<br />
+
**[[3oc7]], [[3p85]], [[3q1t]], [[3qyr]], [[4lk5]], [[4knp]] – MaECH – ''Mycobacterium avium''<br />
**[[3h81]], [[3he2]], [[3pzk]], [[4jjt]], [[4z0m]], [[5kjp]] – MtECH – ''Mycobacterium tuberculosis''<br />
**[[3h81]], [[3he2]], [[3pzk]], [[4jjt]], [[4z0m]], [[5kjp]] – MtECH – ''Mycobacterium tuberculosis''<br />
**[[3t3w]] – ECH – ''Mycobacterium thermoresistibile''<br />
**[[3t3w]] – ECH – ''Mycobacterium thermoresistibile''<br />
**[[3r6h]], [[3qmj]], [[3qka]] , [[3qre]], [[3qxi]], [[4di1]], [[4f47]] – MmECH – ''Mycobacterium marinum''<br />
**[[3r6h]], [[3qmj]], [[3qka]] , [[3qre]], [[3qxi]], [[4di1]], [[4f47]] – MmECH – ''Mycobacterium marinum''<br />
 +
**[[6c7c]] – ECH – ''Mycobacterium ulcerans''<br />
 +
**[[5z7r]] – ECH – ''Clostridium acetobutylicum''<br />
**[[4j2u]] – ECH – ''Rhodobacter sphaeroides''<br />
**[[4j2u]] – ECH – ''Rhodobacter sphaeroides''<br />
**[[4jyl]] – ECH – ''Thermoplasma volcanium''<br />
**[[4jyl]] – ECH – ''Thermoplasma volcanium''<br />

Revision as of 10:27, 13 May 2018

Structure of enoyl-CoA hydratase complex with hexadienoyl-CoA (PDB code 1mj3).

Drag the structure with the mouse to rotate

3D structures of enoyl-CoA hydratase

Updated on 13-May-2018


References

  1. Agnihotri G, Liu HW. Enoyl-CoA hydratase. reaction, mechanism, and inhibition. Bioorg Med Chem. 2003 Jan 2;11(1):9-20. PMID:12467702
  2. Sakai C, Yamaguchi S, Sasaki M, Miyamoto Y, Matsushima Y, Goto Y. ECHS1 mutations cause combined respiratory chain deficiency resulting in Leigh syndrome. Hum Mutat. 2015 Feb;36(2):232-9. doi: 10.1002/humu.22730. PMID:25393721 doi:http://dx.doi.org/10.1002/humu.22730
  3. Bell AF, Feng Y, Hofstein HA, Parikh S, Wu J, Rudolph MJ, Kisker C, Whitty A, Tonge PJ. Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers. Chem Biol. 2002 Nov;9(11):1247-55. PMID:12445775

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Michal Harel, Alexander Berchansky

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