Elongation factor

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Line 29: Line 29:
*EF-Tu
*EF-Tu
-
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]] – EcEF – ''Escherichia coli''<BR />
+
**[[1efm]], [[1efc]], [[1dg1]], [[2fx3]], [[1etu]], [[5mi3]] – EcEF – ''Escherichia coli''<BR />
 +
**[[5mi8]], [[5mi9]] – EcEF (mutant) <br />
**[[1qzd]] – EcEF – Cryo EM<BR />
**[[1qzd]] – EcEF – Cryo EM<BR />
**[[3u2q]] – EcEF + drug<BR />
**[[3u2q]] – EcEF + drug<BR />
Line 40: Line 41:
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
**[[4j0q]] – EF – ''Pseudomonas putida''<br />
**[[4j0q]] – EF – ''Pseudomonas putida''<br />
 +
**[[5w75]] – EF – ''Thermotoga neapolitana''<br />
*''EF-Tu complex with antibiotics''
*''EF-Tu complex with antibiotics''
Line 66: Line 68:
**[[3wy9]] – PhEF + L12 <br />
**[[3wy9]] – PhEF + L12 <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
 +
**[[5i4r]], [[5i4q]] – EcEF + CDIA + CDII <br />
**[[4zv4]] – PaEF + TSE6 - ''Pseudomonas aeruginosa''<br />
**[[4zv4]] – PaEF + TSE6 - ''Pseudomonas aeruginosa''<br />
Line 107: Line 110:
**[[2e5n]] – hEF N2 domain - NMR<BR />
**[[2e5n]] – hEF N2 domain - NMR<BR />
 +
**[[5jw9]] – hEF + AFF4 peptide<br />
*EF-G
*EF-G
Line 125: Line 129:
**[[5ty0]] – EF N terminal – ''Legionella pneumophila''<br />
**[[5ty0]] – EF N terminal – ''Legionella pneumophila''<br />
**[[5vh6]] – EF N terminal – ''Bacillus subtilis''<br />
**[[5vh6]] – EF N terminal – ''Bacillus subtilis''<br />
 +
**[[6b8d]] – EF N terminal – ''Haemophilus influenzae''<br />
*''EF-G in the ribosome''
*''EF-G in the ribosome''
Line 156: Line 161:
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[5j3b]] – EF – ''Acinetobacter baumannii''<br />
**[[5j3b]] – EF – ''Acinetobacter baumannii''<br />
 +
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
 +
*EF-Ts
*EF-Ts
Line 170: Line 177:
**[[4c0s]] – rEF α-2 – rabbit<br />
**[[4c0s]] – rEF α-2 – rabbit<br />
**[[5dqs]] – hEF β+γ <br />
**[[5dqs]] – hEF β+γ <br />
-
**[[1nhy]] – yEF γ N terminal
+
**[[5jpo]] – hEF γ+δ <br />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
 +
**[[5o8w]] – yEF α+β <br />
 +
**[[1nhy]] – yEF γ N terminal<br />
*EF-2
*EF-2
Line 184: Line 193:
**[[2p8w]], [[2p8x]], [[3dny]] - yEF in 80S ribosome – Cryo EM<BR />
**[[2p8w]], [[2p8x]], [[3dny]] - yEF in 80S ribosome – Cryo EM<BR />
**[[2p8y]], [[2p8z]] - yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
**[[2p8y]], [[2p8z]] - yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
 +
**[[5h7j]] - PhEF <BR />
 +
**[[5h7l]] - PhEF + L12<BR />
 +
**[[5h7k]] - PhEF + GDP<BR />
*EF-3
*EF-3
Line 210: Line 222:
**[[2pjp]] – EcEF + RNA<br />
**[[2pjp]] – EcEF + RNA<br />
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
**[[5izk]], [[5izl]], [[5izm]] – hEF + GDP derivative<BR />
 +
 +
*EF-Spt4 + EF-Spt5
 +
 +
**[[5xon]], [[5xog]] – EF-Spt4 + EF-Spt5 + EF-Tfiis + RNA polymerase II - ''Komagataella phaffii'' - Cryo EM<br />
 +
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
 +
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
 +
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
 +
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
*EF-Spt5
*EF-Spt5
-
**[[2do3]], [[2e6z]], [[2e70]] – hEF KOW motif – NMR<BR />
+
**[[2do3]], [[2e6z]], [[2e70]] – hEF KOW motif residues 694-757 – NMR<BR />
 +
**[[5ohq]] – hEF KOW6-KOW7 domain residues 939-1087<br />
 +
**[[5oho]] – hEF KOWX-KOW4 domain residues 536-646<br />
 +
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
 +
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
**[[2exu]] – yEF<BR />
**[[2exu]] – yEF<BR />
-
**[[3h7h]] – hEF + hEF-Spt4
 
*EF-Spt6
*EF-Spt6
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
-
**[[3psf]], [[3psi]] – yEF core domain<BR />
+
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
-
**[[3psj]], [[3psk]] – yEF SH2 domain<BR />
+
**[[3psj]], [[3psk]] – yEF SH2 domain residues 1247-1451<BR />
-
**[[2l3t]] - yEF SH2 domain]] - NMR<BR />
+
**[[5vkl]], [[5vko]] – yEF SH2 domain + RPB1 peptide<br />
-
**[[3oak]] – yEF + transcription factor IWS1
+
**[[2l3t]] - yEF SH2 domain - NMR<BR />
 +
**[[3oak]] – yEF + transcription factor IWS1<br />
 +
**[[4z2n]] – hEF middle domain residues 644-930<br />
 +
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
 +
 
 +
*EF-Spt16
 +
 
 +
**[[5umu]], [[5umt]] – hEF<br />
 +
**[[5e5b]] - hEF N-terminal<BR />
 +
 
 +
*EF-M2-1
 +
 
 +
**[[5nkx]], [[5noh]] – EF core domain – human respiratory cyncytial virus<br />
 +
 
 +
*EF-TEFM mitochondrial
 +
 
 +
**[[5ol9]] - hEF N-terminal<br />
 +
**[[5ol8]] - hEF C-terminal<br />
 +
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
*EF-CA150
*EF-CA150
Line 234: Line 275:
**[[1lqb]], [[1lm8]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α<br />
**[[1lqb]], [[1lm8]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α<br />
-
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]] - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor<br />
+
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[6fmi]], [[6fmj]], [[6fmk]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]] - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor<br />
-
**[[3zrf]] - hEloBC + von-Hippel Lindau disease tumor suppressor<br />
+
**[[5t35]] - hEloBC + von-Hippel Lindau disease tumor suppressor + BRD4<br />
-
**[[2c9w]], [[2izv]], [[2jz3]] – hEloBC + suppressor of cytokine signaling<br />
+
**[[4wqo]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 <br />
 +
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
 +
**[[3zrf]], [[5lli]] - hEloBC + von-Hippel Lindau disease tumor suppressor<br />
 +
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
 +
**[[6c5x]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
**[[3dcg]] – hEloBC + virion infectivity factor<br />
**[[3dcg]] – hEloBC + virion infectivity factor<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />

Revision as of 10:08, 14 May 2018

Structure of EF-Tu (cyan and magenta) with EF-Ts (green and yellow) (PDB entry 1efu)

Drag the structure with the mouse to rotate

3D structures of elongation factor

Updated on 14-May-2018


References

  1. ↑ Takeshita D, Tomita K. Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15733-8. Epub 2010 Aug 23. PMID:20798060 doi:http://dx.doi.org/10.1073/pnas.1006559107
  2. ↑ Jorgensen R, Merrill AR, Andersen GR. The life and death of translation elongation factor 2. Biochem Soc Trans. 2006 Feb;34(Pt 1):1-6. PMID:16246167 doi:http://dx.doi.org/10.1042/BST20060001
  3. ↑ Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R. The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature. 1996 Feb 8;379(6565):511-8. PMID:8596629 doi:http://dx.doi.org/10.1038/379511a0

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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