Beta-adrenergic receptor kinase
From Proteopedia
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'''Beta adrenergic receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) as well as many other G protein-coupled receptors when they is occupied by the agonist thus causing their desensitization. BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref> | '''Beta adrenergic receptor kinase''' (BARK), currently termed GRK2 for G protein-coupled receptor kinase 2, is an intracellular serine/threonine kinase. BARK is activated by protein kinase A. BARK phosphorylates the β adregenic receptor (BAR) as well as many other G protein-coupled receptors when they is occupied by the agonist thus causing their desensitization. BARK belongs to the family of G protein-coupled receptor kinases (GRK) that encompases 5 different isozymes. <ref>PMID:2871555</ref> | ||
| - | <scene name='70/705677/Cv/ | + | <scene name='70/705677/Cv/4'>Human BARK1 complex with RNA and Mg+2 ion</scene>; |
| - | <scene name='70/705677/Cv/ | + | <scene name='70/705677/Cv/5'>Mg+2 ion coordination site</scene> (PDB code [[3uzt]]).<ref>PMID:22727813</ref> |
</StructureSection> | </StructureSection> | ||
== 3D Structures of β adrenergic receptor kinase == | == 3D Structures of β adrenergic receptor kinase == | ||
Revision as of 10:50, 17 May 2018
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3D Structures of β adrenergic receptor kinase
Updated on 17-May-2018
1ym7 – bBARK1 (mutant) - bovine
5uvc, 5uuu – hBARK1 + inhibitor - human
4pnk, 3cik, 5he3 – hBARK1 + guanine-nucleotide binding protein G β,γ subunits
3psc, 5he0, 5he1, 5he2 – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits
4mk0, 3v5w – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + paroxetine derivative
3uzs – hBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + RNA
3uzt – hBARK1 (mutant) + RNA
3krw, 3krx, 5wg3, 5wg4, 5wg5, 5ukk, 5ukl, 5he3 – hBARK1 + guanine-nucleotide binding protein G β,γ subunits + inhibitor
3pvu, 3pvw, 5ukm, 5he0, 5he1, 5he2 – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits + inhibitor
2bcj – bBARK1 (mutant) + guanine-nucleotide binding protein G α,β,γ subunits
1omw – bBARK1 (mutant) + guanine-nucleotide binding protein G β,γ subunits
References
- ↑ Benovic JL, Strasser RH, Caron MG, Lefkowitz RJ. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc Natl Acad Sci U S A. 1986 May;83(9):2797-801. PMID:2871555
- ↑ Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 Jun 21. PMID:22727813 doi:10.1016/j.str.2012.05.002
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