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5vok

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'''Unreleased structure'''
 
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The entry 5vok is ON HOLD until Paper Publication
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==Crystal structure of the C7orf59-HBXIP dimer==
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<StructureSection load='5vok' size='340' side='right' caption='[[5vok]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vok]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOK FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vok OCA], [http://pdbe.org/5vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vok RCSB], [http://www.ebi.ac.uk/pdbsum/5vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vok ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aparicio, R]]
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[[Category: Bar-Peled, L]]
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[[Category: Nascimento, A F.Z]]
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[[Category: Rasheed, N]]
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[[Category: Sabatini, D M]]
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[[Category: Shen, K]]
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[[Category: Smetana, J H.C]]
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[[Category: C7orf59]]
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[[Category: Mtor]]
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[[Category: Ragulator]]
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[[Category: Roadblock]]
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[[Category: Signaling protein]]

Revision as of 07:14, 23 May 2018

Crystal structure of the C7orf59-HBXIP dimer

5vok, resolution 2.89Å

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