2il9
From Proteopedia
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|PDB= 2il9 |SIZE=350|CAPTION= <scene name='initialview01'>2il9</scene>, resolution 3.100Å | |PDB= 2il9 |SIZE=350|CAPTION= <scene name='initialview01'>2il9</scene>, resolution 3.100Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2il9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2il9 OCA], [http://www.ebi.ac.uk/pdbsum/2il9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2il9 RCSB]</span> | ||
}} | }} | ||
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[[Category: Kieft, J S.]] | [[Category: Kieft, J S.]] | ||
[[Category: Pfingsten, J S.]] | [[Category: Pfingsten, J S.]] | ||
| - | [[Category: | + | [[Category: double-nested pseudoknot]] |
| + | [[Category: ire]] | ||
| + | [[Category: psiv]] | ||
| + | [[Category: ribosomal binding domain]] | ||
| + | [[Category: rna]] | ||
| + | [[Category: under wound helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:45:43 2008'' |
Revision as of 00:45, 31 March 2008
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| , resolution 3.100Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms
Overview
Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome using a single structured RNA. Here we present the crystal structures of the ribosome-binding domain from a Dicistroviridae intergenic region IRES at 3.1 angstrom resolution, providing a view of the prefolded architecture of an all-RNA translation initiation apparatus. Docking of the structure into cryo-electron microscopy reconstructions of an IRES-ribosome complex suggests a model for ribosome manipulation by a dynamic IRES RNA.
About this Structure
2IL9 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structural basis for ribosome recruitment and manipulation by a viral IRES RNA., Pfingsten JS, Costantino DA, Kieft JS, Science. 2006 Dec 1;314(5804):1450-4. Epub 2006 Nov 23. PMID:17124290
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